TY  - JOUR
AU  - Geijsen, Anne J M R
AU  - Ulvik, Arve
AU  - Gigic, Biljana
AU  - Kok, Dieuwertje E
AU  - van Duijnhoven, Fränzel J B
AU  - Holowatyj, Andreana N
AU  - Brezina, Stefanie
AU  - van Roekel, Eline H
AU  - Baierl, Andreas
AU  - Bergmann, Michael M
AU  - Böhm, Jürgen
AU  - Bours, Martijn J L
AU  - Brenner, Hermann
AU  - Breukink, Stéphanie O
AU  - Bronner, Mary P
AU  - Chang-Claude, Jenny
AU  - de Wilt, Johannes H W
AU  - Grady, William M
AU  - Grünberger, Thomas
AU  - Gumpenberger, Tanja
AU  - Herpel, Esther
AU  - Hoffmeister, Michael
AU  - Huang, Lyen C
AU  - Jedrzkiewicz, Jolanta D
AU  - Keulen, Eric T P
AU  - Kiblawi, Rama
AU  - Kölsch, Torsten
AU  - Koole, Janna L
AU  - Kosma, Katharina
AU  - Kouwenhoven, Ewout A
AU  - Kruyt, Flip M
AU  - Kvalheim, Gry
AU  - Li, Christopher I
AU  - Lin, Tengda
AU  - Ose, Jennifer
AU  - Pickron, T Bartley
AU  - Scaife, Courtney L
AU  - Schirmacher, Peter
AU  - Schneider, Martin A
AU  - Schrotz-King, Petra
AU  - Singer, Marie C
AU  - Swanson, Eric R
AU  - van Duijvendijk, Peter
AU  - van Halteren, Henk K
AU  - van Zutphen, Moniek
AU  - Vickers, Kathy
AU  - Vogelaar, F Jeroen
AU  - Wesselink, Evertine
AU  - Habermann, Nina
AU  - Ulrich, Alexis B
AU  - Ueland, Per M
AU  - Weijenberg, Matty P
AU  - Gsur, Andrea
AU  - Ulrich, Cornelia M
AU  - Kampman, Ellen
TI  - Circulating Folate and Folic Acid Concentrations: Associations With Colorectal Cancer Recurrence and Survival.
JO  - JNCI cancer spectrum
VL  - 4
IS  - 5
SN  - 2515-5091
CY  - Oxford
PB  - Oxford University Press
M1  - DKFZ-2020-02351
SP  - pkaa051
PY  - 2020
AB  - Folates, including folic acid, may play a dual role in colorectal cancer development. Folate is suggested to be protective in early carcinogenesis but could accelerate growth of premalignant lesions or micrometastases. Whether circulating concentrations of folate and folic acid, measured around time of diagnosis, are associated with recurrence and survival in colorectal cancer patients is largely unknown.Circulating concentrations of folate, folic acid, and folate catabolites p-aminobenzoylglutamate and p-acetamidobenzoylglutamate were measured by liquid chromatography-tandem mass spectrometry at diagnosis in 2024 stage I-III colorectal cancer patients from European and US patient cohort studies. Multivariable-adjusted Cox proportional hazard models were used to assess associations between folate, folic acid, and folate catabolites concentrations with recurrence, overall survival, and disease-free survival.No statistically significant associations were observed between folate, p-aminobenzoylglutamate, and p-acetamidobenzoylglutamate concentrations and recurrence, overall survival, and disease-free survival, with hazard ratios ranging from 0.92 to 1.16. The detection of folic acid in the circulation (yes or no) was not associated with any outcome. However, among patients with detectable folic acid concentrations (n = 296), a higher risk of recurrence was observed for each twofold increase in folic acid (hazard ratio = 1.31, 95
LB  - PUB:(DE-HGF)16
C6  - pmid:33134831
C2  - pmc:PMC7583160
DO  - DOI:10.1093/jncics/pkaa051
UR  - https://inrepo02.dkfz.de/record/164265
ER  -