TY  - JOUR
AU  - Pagliari, Francesca
AU  - Marafioti, Maria Grazia
AU  - Genard, Geraldine
AU  - Candeloro, Patrizio
AU  - Viglietto, Giuseppe
AU  - Seco, Joao
AU  - Tirinato, Luca
TI  - ssRNA Virus and Host Lipid Rearrangements: Is There a Role for Lipid Droplets in SARS-CoV-2 Infection?
JO  - Frontiers in molecular biosciences
VL  - 7
SN  - 2296-889X
CY  - Lausanne
PB  - Frontiers
M1  - DKFZ-2020-02352
SP  - 578964
PY  - 2020
N1  - #EA:E041#LA:E041#
AB  - Since its appearance, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has immediately alarmed the World Health Organization for its very high contagiousness and the complexity of patient clinical profiles. The worldwide scientific community is today gathered in a massive effort in order to develop safe vaccines and effective therapies in the shortest possible time. Every day, new pieces of SARS-CoV-2 infective puzzle are disclosed. Based on knowledge gained with other related coronaviruses and, more in general, on single-strand RNA viruses, we highlight underexplored molecular routes in which lipids and lipid droplets (LDs) might serve essential functions in viral infections. In fact, both lipid homeostasis and the pathways connected to lipids seem to be fundamental in all phases of the coronavirus infection. This review aims at describing potential roles for lipid and LDs in host-virus interactions and suggesting LDs as new and central cellular organelles to be investigated as potential targets against SARS-CoV-2 infection.
LB  - PUB:(DE-HGF)16
C6  - pmid:33134318
C2  - pmc:PMC7579428
DO  - DOI:10.3389/fmolb.2020.578964
UR  - https://inrepo02.dkfz.de/record/164266
ER  -