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@ARTICLE{Deutelmoser:164288,
      author       = {H. Deutelmoser$^*$ and J. Lorenzo Bermejo and A. Benner$^*$
                      and K. Weigl$^*$ and H. A. Park$^*$ and M. Haffa$^*$ and E.
                      Herpel and M. Schneider and C. M. Ulrich$^*$ and M.
                      Hoffmeister$^*$ and J. Chang-Claude$^*$ and H. Brenner$^*$
                      and D. Scherer$^*$},
      title        = {{G}enotype-{B}ased {G}ene {E}xpression in {C}olon
                      {T}issue-{P}rediction {A}ccuracy and {R}elationship with the
                      {P}rognosis of {C}olorectal {C}ancer {P}atients.},
      journal      = {International journal of molecular sciences},
      volume       = {21},
      number       = {21},
      issn         = {1422-0067},
      address      = {Basel},
      publisher    = {Molecular Diversity Preservation International},
      reportid     = {DKFZ-2020-02371},
      pages        = {8150},
      year         = {2020},
      note         = {#EA:C120#LA:C120#},
      abstract     = {Colorectal cancer (CRC) survival has environmental and
                      inherited components. The expression of specific genes can
                      be inferred based on individual genotypes-so called
                      expression quantitative trait loci. In this study, we used
                      the PrediXcan method to predict gene expression in normal
                      colon tissue using individual genotype data from 91 CRC
                      patients and examined the correlation ρ between predicted
                      and measured gene expression levels. Out of 5434 predicted
                      genes, $58\%$ showed a negative ρ value and only $16\%$
                      presented a ρ higher than 0.10. We subsequently
                      investigated the association between genotype-based gene
                      expression in colon tissue for genes with ρ > 0.10 and
                      survival of 4436 CRC patients. We identified an inverse
                      association between the predicted expression of ARID3B and
                      CRC-specific survival for patients with a body mass index
                      greater than or equal to 30 kg/m2 (HR (hazard ratio) = 0.66
                      for an expression higher vs. lower than the median, p =
                      0.005). This association was validated using genotype and
                      clinical data from the UK Biobank (HR = 0.74, p = 0.04). In
                      addition to the identification of ARID3B expression in
                      normal colon tissue as a candidate prognostic biomarker for
                      obese CRC patients, our study illustrates the challenges of
                      genotype-based prediction of gene expression, and the
                      advantage of reassessing the prediction accuracy in a subset
                      of the study population using measured gene expression
                      data.},
      cin          = {C120 / C060 / C070 / C020 / B280 / HD01},
      ddc          = {540},
      cid          = {I:(DE-He78)C120-20160331 / I:(DE-He78)C060-20160331 /
                      I:(DE-He78)C070-20160331 / I:(DE-He78)C020-20160331 /
                      I:(DE-He78)B280-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33142733},
      doi          = {10.3390/ijms21218150},
      url          = {https://inrepo02.dkfz.de/record/164288},
}