%0 Journal Article
%A Sievers, Philipp
%A Sill, Martin
%A Schrimpf, Daniel
%A Stichel, Damian
%A Reuß, David
%A Sturm, Dominik
%A Hench, Jürgen
%A Frank, Stephan
%A Krskova, Lenka
%A Vicha, Ales
%A Zapotocky, Michal
%A Bison, Brigitte
%A Castel, David
%A Grill, Jacques
%A Debily, Marie-Anne
%A Harter, Patrick N
%A Snuderl, Matija
%A Kramm, Christof M
%A Reifenberger, Guido
%A Korshunov, Andrey
%A Jabado, Nada
%A Wesseling, Pieter
%A Wick, Wolfgang
%A Solomon, David A
%A Perry, Arie
%A Jacques, Thomas S
%A Jones, Chris
%A Witt, Olaf
%A Pfister, Stefan
%A von Deimling, Andreas
%A Jones, David
%A Sahm, Felix
%T A subset of pediatric-type thalamic gliomas share a distinct DNA methylation profile, H3K27me3 loss and frequent alteration of EGFR.
%J Neuro-Oncology
%V 23
%N 1
%@ 1523-5866
%C Oxford
%I Oxford Univ. Press
%M DKFZ-2020-02381
%P 34-43
%D 2021
%Z 2021 Jan 30;23(1):34-43 #EA:B360#LA:B300#
%X Malignant astrocytic gliomas in children show a remarkable biological and clinical diversity. Small in-frame insertions or missense mutations in the EGFR gene have recently been identified in a distinct subset of pediatric-type bithalamic gliomas with a unique DNA methylation pattern.Here, we investigated an epigenetically homogeneous cohort of malignant gliomas (n=58) distinct from other subtypes and enriched for pediatric cases and thalamic location, in comparison with this recently identified subtype of pediatric bithalamic gliomas.EGFR gene amplification was detected in 16/58 (27
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:33130881
%R 10.1093/neuonc/noaa251
%U https://inrepo02.dkfz.de/record/164298