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@ARTICLE{Mukama:165820,
      author       = {T. Mukama$^*$ and M. Fallah$^*$ and H. Brenner$^*$ and X.
                      Xu$^*$ and K. Sundquist and J. Sundquist and E.
                      Kharazmi$^*$},
      title        = {{R}isk of invasive breast cancer in relatives of patients
                      with breast carcinoma in situ: a prospective cohort study.},
      journal      = {BMC medicine},
      volume       = {18},
      number       = {1},
      issn         = {1741-7015},
      address      = {Heidelberg [u.a.]},
      publisher    = {Springer},
      reportid     = {DKFZ-2020-02400},
      pages        = {295},
      year         = {2020},
      note         = {#EA:C120#LA:C120#},
      abstract     = {Wide implementation of mammography screening has resulted
                      in increased numbers of women diagnosed with breast
                      carcinoma in situ. We aimed to determine the risk of
                      invasive breast cancer in relatives of patients with breast
                      carcinoma in situ in comparison to the risk in relatives of
                      patients with invasive breast cancer.We analyzed the
                      occurrence of cancer in a nationwide cohort including all
                      5,099,172 Swedish women born after 1931 with at least one
                      known first-degree relative. This was a record linkage study
                      of Swedish family cancer datasets, including cancer registry
                      data collected from January 1, 1958, to December 31, 2015.
                      We calculated standardized incidence ratios (SIRs) and
                      10-year cumulative risk of breast cancer diagnosis for women
                      with a family history of in situ and invasive breast
                      cancer.Having one first-degree relative with breast
                      carcinoma in situ was associated with $50\%$ increased risk
                      of invasive breast cancer (SIR = 1.5, $95\%$ CI 1.4-1.7)
                      when compared to those who had no family history of invasive
                      breast cancer or breast carcinoma in situ in either first-
                      or second-degree relatives. Similarly, having one
                      first-degree relative with invasive breast cancer was
                      associated with $70\%$ (1.7, 1.7-1.8) increased risk. The
                      10-year cumulative risk for women at age 50 with a relative
                      with breast carcinoma in situ was $3.5\%$ $(2.9-3.9\%)$ and
                      was not significantly different from $3.7\%$ $(3.6-3.8\%)$
                      risk for 50-year-old women with a relative with invasive
                      breast cancer $(95\%$ confidence intervals overlapped).The
                      risk of invasive breast cancer for women with a family
                      history of breast carcinoma in situ was comparable to that
                      for women with a family history of invasive breast cancer.
                      Therefore, family history of breast carcinoma in situ should
                      not be overlooked in recommendations for breast cancer
                      prevention for women with a family history of breast
                      cancer.},
      cin          = {C120 / C070 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C120-20160331 / I:(DE-He78)C070-20160331 /
                      I:(DE-He78)HD01-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33148280},
      pmc          = {pmc:PMC7643418},
      doi          = {10.1186/s12916-020-01772-x},
      url          = {https://inrepo02.dkfz.de/record/165820},
}