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000165842 0247_ $$2doi$$a10.1002/mrm.28576
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000165842 041__ $$aeng
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000165842 1001_ $$00000-0002-6393-5415$$aAlhulail, Ahmad A$$b0
000165842 245__ $$aFast in vivo 23 Na imaging and T 2 ∗ mapping using accelerated 2D-FID UTE magnetic resonance spectroscopic imaging at 3 T: Proof of concept and reliability study.
000165842 260__ $$aNew York, NY [u.a.]$$bWiley-Liss$$c2021
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000165842 500__ $$a2021 Apr;85(4):1783-1794
000165842 520__ $$aTo implement an accelerated MR-acquisition method allowing to map T 2 ∗ relaxation and absolute concentration of sodium within skeletal muscles at 3T.A fast-UTE-2D density-weighted concentric-ring-trajectory 23 Na-MRSI technique was used to acquire 64 time points of FID with a spectral bandwidth of 312.5 Hz with an in-plane resolution of 2.5 × 2.5 mm2 in ~15 min. The fast-relaxing 23 Na signal was localized with a single-shot, inversion-recovery-based, non-echo (SIRENE) outer volume suppression (OVS) method. The sequence was verified using simulation and phantom studies before implementing it in human calf muscles. To evaluate the 2D-SIRENE-MRSI (UTE = 0.55 ms) imaging performance, it was compared to a 3D-MRI (UTE = 0.3 ms) sequence. Both data sets were acquired within 2 same-day sessions to assess repeatability. The T 2 ∗ values were fitted voxel-by-voxel using a biexponential model for the 2D-MRSI data. Finally, intra-subject coefficients of variation (CV) were estimated.The MRSI-FID data allowed us to map the fast and slow components of T 2 ∗ in the calf muscles. The spatial distributions of 23 Na concentration for both MRSI and 3D-MRI acquisitions were significantly correlated (P < .001). The test-retest analysis rendered high repeatability for MRSI with a CV of 5%. The mean T 2 Fast ∗ in muscles was 0.7 ± 0.1 ms (contribution fraction = 37%), whereas T 2 Slow ∗ was 13.2 ± 0.2 ms (63%). The mean absolute muscle 23 Na concentration calculated from the T 2 ∗ -corrected data was 28.6 ± 3.3 mM.The proposed MRSI technique is a reliable technique to map sodium's absolute concentration and T 2 ∗ within a clinically acceptable scan time at 3T.
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000165842 7001_ $$aXia, Pingyu$$b1
000165842 7001_ $$aShen, Xin$$b2
000165842 7001_ $$aNichols, Miranda$$b3
000165842 7001_ $$aVolety, Srijyotsna$$b4
000165842 7001_ $$aFarley, Nicholas$$b5
000165842 7001_ $$00000-0001-9037-2585$$aThomas, Micheal Albert$$b6
000165842 7001_ $$0P:(DE-He78)054fd7a5195b75b11fbdc5c360276011$$aNagel, Armin M$$b7$$udkfz
000165842 7001_ $$aDydak, Ulrike$$b8
000165842 7001_ $$00000-0001-5376-0431$$aEmir, Uzay E$$b9
000165842 773__ $$0PERI:(DE-600)1493786-4$$a10.1002/mrm.28576$$gp. mrm.28576$$n4$$p1783-1794$$tMagnetic resonance in medicine$$v85$$x1522-2594$$y2021
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