TY  - JOUR
AU  - Alhulail, Ahmad A
AU  - Xia, Pingyu
AU  - Shen, Xin
AU  - Nichols, Miranda
AU  - Volety, Srijyotsna
AU  - Farley, Nicholas
AU  - Thomas, Micheal Albert
AU  - Nagel, Armin M
AU  - Dydak, Ulrike
AU  - Emir, Uzay E
TI  - Fast in vivo 23 Na imaging and T 2 ∗ mapping using accelerated 2D-FID UTE magnetic resonance spectroscopic imaging at 3 T: Proof of concept and reliability study.
JO  - Magnetic resonance in medicine
VL  - 85
IS  - 4
SN  - 1522-2594
CY  - New York, NY [u.a.]
PB  - Wiley-Liss
M1  - DKFZ-2020-02418
SP  - 1783-1794
PY  - 2021
N1  - 2021 Apr;85(4):1783-1794
AB  - To implement an accelerated MR-acquisition method allowing to map T 2 ∗ relaxation and absolute concentration of sodium within skeletal muscles at 3T.A fast-UTE-2D density-weighted concentric-ring-trajectory 23 Na-MRSI technique was used to acquire 64 time points of FID with a spectral bandwidth of 312.5 Hz with an in-plane resolution of 2.5 × 2.5 mm2 in  15 min. The fast-relaxing 23 Na signal was localized with a single-shot, inversion-recovery-based, non-echo (SIRENE) outer volume suppression (OVS) method. The sequence was verified using simulation and phantom studies before implementing it in human calf muscles. To evaluate the 2D-SIRENE-MRSI (UTE = 0.55 ms) imaging performance, it was compared to a 3D-MRI (UTE = 0.3 ms) sequence. Both data sets were acquired within 2 same-day sessions to assess repeatability. The T 2 ∗ values were fitted voxel-by-voxel using a biexponential model for the 2D-MRSI data. Finally, intra-subject coefficients of variation (CV) were estimated.The MRSI-FID data allowed us to map the fast and slow components of T 2 ∗ in the calf muscles. The spatial distributions of 23 Na concentration for both MRSI and 3D-MRI acquisitions were significantly correlated (P < .001). The test-retest analysis rendered high repeatability for MRSI with a CV of 5
LB  - PUB:(DE-HGF)16
C6  - pmid:33166096
DO  - DOI:10.1002/mrm.28576
UR  - https://inrepo02.dkfz.de/record/165842
ER  -