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| 024 | 7 | _ | |a 10.1002/mrm.28576 |2 doi |
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| 024 | 7 | _ | |a 0740-3194 |2 ISSN |
| 024 | 7 | _ | |a 1522-2594 |2 ISSN |
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| 037 | _ | _ | |a DKFZ-2020-02418 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Alhulail, Ahmad A |0 0000-0002-6393-5415 |b 0 |
| 245 | _ | _ | |a Fast in vivo 23 Na imaging and T 2 ∗ mapping using accelerated 2D-FID UTE magnetic resonance spectroscopic imaging at 3 T: Proof of concept and reliability study. |
| 260 | _ | _ | |a New York, NY [u.a.] |c 2021 |b Wiley-Liss |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1617964158_3293 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a 2021 Apr;85(4):1783-1794 |
| 520 | _ | _ | |a To implement an accelerated MR-acquisition method allowing to map T 2 ∗ relaxation and absolute concentration of sodium within skeletal muscles at 3T.A fast-UTE-2D density-weighted concentric-ring-trajectory 23 Na-MRSI technique was used to acquire 64 time points of FID with a spectral bandwidth of 312.5 Hz with an in-plane resolution of 2.5 × 2.5 mm2 in ~15 min. The fast-relaxing 23 Na signal was localized with a single-shot, inversion-recovery-based, non-echo (SIRENE) outer volume suppression (OVS) method. The sequence was verified using simulation and phantom studies before implementing it in human calf muscles. To evaluate the 2D-SIRENE-MRSI (UTE = 0.55 ms) imaging performance, it was compared to a 3D-MRI (UTE = 0.3 ms) sequence. Both data sets were acquired within 2 same-day sessions to assess repeatability. The T 2 ∗ values were fitted voxel-by-voxel using a biexponential model for the 2D-MRSI data. Finally, intra-subject coefficients of variation (CV) were estimated.The MRSI-FID data allowed us to map the fast and slow components of T 2 ∗ in the calf muscles. The spatial distributions of 23 Na concentration for both MRSI and 3D-MRI acquisitions were significantly correlated (P < .001). The test-retest analysis rendered high repeatability for MRSI with a CV of 5%. The mean T 2 Fast ∗ in muscles was 0.7 ± 0.1 ms (contribution fraction = 37%), whereas T 2 Slow ∗ was 13.2 ± 0.2 ms (63%). The mean absolute muscle 23 Na concentration calculated from the T 2 ∗ -corrected data was 28.6 ± 3.3 mM.The proposed MRSI technique is a reliable technique to map sodium's absolute concentration and T 2 ∗ within a clinically acceptable scan time at 3T. |
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| 700 | 1 | _ | |a Xia, Pingyu |b 1 |
| 700 | 1 | _ | |a Shen, Xin |b 2 |
| 700 | 1 | _ | |a Nichols, Miranda |b 3 |
| 700 | 1 | _ | |a Volety, Srijyotsna |b 4 |
| 700 | 1 | _ | |a Farley, Nicholas |b 5 |
| 700 | 1 | _ | |a Thomas, Micheal Albert |0 0000-0001-9037-2585 |b 6 |
| 700 | 1 | _ | |a Nagel, Armin M |0 P:(DE-He78)054fd7a5195b75b11fbdc5c360276011 |b 7 |u dkfz |
| 700 | 1 | _ | |a Dydak, Ulrike |b 8 |
| 700 | 1 | _ | |a Emir, Uzay E |0 0000-0001-5376-0431 |b 9 |
| 773 | _ | _ | |a 10.1002/mrm.28576 |g p. mrm.28576 |0 PERI:(DE-600)1493786-4 |n 4 |p 1783-1794 |t Magnetic resonance in medicine |v 85 |y 2021 |x 1522-2594 |
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