%0 Journal Article
%A Mata, Douglas A
%A Benhamida, Jamal K
%A Lin, Andrew L
%A Vanderbilt, Chad M
%A Yang, Soo-Ryum
%A Villafania, Liliana B
%A Ferguson, Donna C
%A Jonsson, Philip
%A Miller, Alexandra M
%A Tabar, Viviane
%A Brennan, Cameron W
%A Moss, Nelson S
%A Sill, Martin
%A Benayed, Ryma
%A Mellinghoff, Ingo K
%A Rosenblum, Marc K
%A Arcila, Maria E
%A Ladanyi, Marc
%A Bale, Tejus A
%T Genetic and epigenetic landscape of IDH-wildtype glioblastomas with FGFR3-TACC3 fusions.
%J Acta Neuropathologica Communications
%V 8
%N 1
%@ 2051-5960
%C London
%I Biomed Central
%M DKFZ-2020-02433
%P 186
%D 2020
%X A subset of glioblastomas (GBMs) harbors potentially druggable oncogenic FGFR3-TACC3 (F3T3) fusions. However, their associated molecular and clinical features are poorly understood. Here we analyze the frequency of F3T3-fusion positivity, its associated genetic and methylation profiles, and its impact on survival in 906 IDH-wildtype GBM patients. We establish an F3T3 prevalence of 4.1
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:33168106
%R 10.1186/s40478-020-01058-6
%U https://inrepo02.dkfz.de/record/165857