TY  - JOUR
AU  - Mata, Douglas A
AU  - Benhamida, Jamal K
AU  - Lin, Andrew L
AU  - Vanderbilt, Chad M
AU  - Yang, Soo-Ryum
AU  - Villafania, Liliana B
AU  - Ferguson, Donna C
AU  - Jonsson, Philip
AU  - Miller, Alexandra M
AU  - Tabar, Viviane
AU  - Brennan, Cameron W
AU  - Moss, Nelson S
AU  - Sill, Martin
AU  - Benayed, Ryma
AU  - Mellinghoff, Ingo K
AU  - Rosenblum, Marc K
AU  - Arcila, Maria E
AU  - Ladanyi, Marc
AU  - Bale, Tejus A
TI  - Genetic and epigenetic landscape of IDH-wildtype glioblastomas with FGFR3-TACC3 fusions.
JO  - Acta Neuropathologica Communications
VL  - 8
IS  - 1
SN  - 2051-5960
CY  - London
PB  - Biomed Central
M1  - DKFZ-2020-02433
SP  - 186
PY  - 2020
AB  - A subset of glioblastomas (GBMs) harbors potentially druggable oncogenic FGFR3-TACC3 (F3T3) fusions. However, their associated molecular and clinical features are poorly understood. Here we analyze the frequency of F3T3-fusion positivity, its associated genetic and methylation profiles, and its impact on survival in 906 IDH-wildtype GBM patients. We establish an F3T3 prevalence of 4.1
LB  - PUB:(DE-HGF)16
C6  - pmid:33168106
DO  - DOI:10.1186/s40478-020-01058-6
UR  - https://inrepo02.dkfz.de/record/165857
ER  -