TY  - JOUR
AU  - Pettersen, Helge Egil Seime
AU  - Volz, Lennart
AU  - Sølie, Jarle Rambo
AU  - Alme, Johan
AU  - Barnaföldi, Gergely Gábor
AU  - Barthel, Rene
AU  - van den Brink, A.
AU  - Borshchov, Viatcheslav
AU  - Chaar, Mamdouh
AU  - Eikeland, Viljar Nilsen
AU  - Genov, Georgi
AU  - Grøttvik, Ola Slettevoll
AU  - Helstrup, Håvard
AU  - Keidel, Ralf
AU  - Kobdaj, Chinorat
AU  - van der Kolk, Naomi
AU  - Mehendale, Shruti
AU  - Meric, Ilker
AU  - Odland, Odd Harald
AU  - Papp, G.
AU  - Peitzmann, Thomas
AU  - Piersimoni, Pierluigi
AU  - Protsenko, Maksym
AU  - Rehman, Attiq Ur
AU  - Richter, Matthias
AU  - Samnøy, Andreas Tefre
AU  - Seco, Joao
AU  - Shafiee, Hesam
AU  - Songmoolnak, Arnon
AU  - Tambave, Ganesh
AU  - Tymchuk, Ihor
AU  - Ullaland, Kjetil
AU  - Varga-Kofarago, Monika
AU  - Wagner, Boris
AU  - Xiao, RenZheng
AU  - Yang, Shiming
AU  - Yokoyama, Hiroki
AU  - Roehrich, Dieter
TI  - Helium radiography with a digital tracking calorimeter-a Monte Carlo study for secondary track rejection.
JO  - Physics in medicine and biology
VL  - 66
IS  - 3
SN  - 1361-6560
CY  - Bristol
PB  - IOP Publ.
M1  - DKFZ-2020-02466
SP  - 035004
PY  - 2021
N1  - 2021 Jan 26;66(3):035004
AB  - Radiation therapy using protons and heavier ions is a fast-growing therapeutic option for cancer patients. A clinical system for particle imaging in particle therapy would enable online patient position verification, estimation of the dose deposition through range monitoring and a reduction of uncertainties in the calculation of the relative stopping power of the patient. Several prototype imaging modalities offer radiography and computed tomography using protons and heavy ions. A Digital Tracking Calorimeter (DTC), currently under development, has been proposed as one such detector. In the DTC 43 longitudinal layers of laterally stacked ALPIDE CMOS monolithic active pixel sensor chips are able to reconstruct a large number of simultaneously recorded proton tracks. In this study, we explored the capability of the DTC for helium imaging which offers favorable spatial resolution over proton imaging. Helium ions exhibit a larger cross section for inelastic nuclear interactions, increasing the number of produced secondaries in the imaged object and in the detector itself. To that end, a filtering process able to remove a large fraction of the secondaries was identified, and the track reconstruction process was adapted for helium ions. By filtering on the energy loss along the tracks, on the incoming angle and on the particle ranges, 97.5
LB  - PUB:(DE-HGF)16
C6  - pmid:33181502
DO  - DOI:10.1088/1361-6560/abca03
UR  - https://inrepo02.dkfz.de/record/165909
ER  -