%0 Journal Article
%A Riexinger, Andreas
%A Martin, Jan
%A Wetscherek, Andreas
%A Kuder, Tristan Anselm
%A Uder, Michael
%A Hensel, Bernhard
%A Laun, Frederik Bernd
%T An optimized b-value distribution for triexponential intravoxel incoherent motion (IVIM) in the liver.
%J Magnetic resonance in medicine
%V 85
%N 4
%@ 1522-2594
%C New York, NY [u.a.]
%I Wiley-Liss
%M DKFZ-2020-02493
%P 2095-2108
%D 2021
%Z 2021 Apr;85(4):2095-2108
%X To find an optimized b-value distribution for reproducible triexponential intravoxel incoherent motion (IVIM) exams in the liver.A numeric optimization of b-value distributions was performed using the triexponential IVIM equation and 27 different IVIM parameter sets. Starting with an initially optimized distribution of 6 b-values, the number of b-values was increased stepwise. Each new b-value was chosen from a set of 64 predefined b-values based on the computed summed relative mean error of the fitted triexponential IVIM parameters. This process was repeated for up to 100 b-values. In simulations and in vivo measurements, optimized b-value distributions were compared to 4 representative distributions found in literature.The first 16 optimized b-values were 0, 0.3, 0.3, 70, 200, 800, 70, 1, 3.5, 5, 70, 1.2, 6, 45, 1.5, and 60 in units of s/mm2 . Low b-values were much more frequent than high b-values. The optimized b-value distribution resulted in a higher fit stability compared to distributions used in literature in both, simulation and in vivo measurements. Using more than 6 b-values, ideally 16 or more, increased the fit stability considerably.Using optimized b-values, the fit uncertainty in triexponential IVIM can be largely reduced. Ideally, 16 or more b-values should be acquired.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:33201549
%R 10.1002/mrm.28582
%U https://inrepo02.dkfz.de/record/165942