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000165942 0247_ $$2ISSN$$a1522-2594
000165942 037__ $$aDKFZ-2020-02493
000165942 041__ $$aeng
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000165942 1001_ $$00000-0002-6346-3526$$aRiexinger, Andreas$$b0
000165942 245__ $$aAn optimized b-value distribution for triexponential intravoxel incoherent motion (IVIM) in the liver.
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000165942 500__ $$a2021 Apr;85(4):2095-2108
000165942 520__ $$aTo find an optimized b-value distribution for reproducible triexponential intravoxel incoherent motion (IVIM) exams in the liver.A numeric optimization of b-value distributions was performed using the triexponential IVIM equation and 27 different IVIM parameter sets. Starting with an initially optimized distribution of 6 b-values, the number of b-values was increased stepwise. Each new b-value was chosen from a set of 64 predefined b-values based on the computed summed relative mean error of the fitted triexponential IVIM parameters. This process was repeated for up to 100 b-values. In simulations and in vivo measurements, optimized b-value distributions were compared to 4 representative distributions found in literature.The first 16 optimized b-values were 0, 0.3, 0.3, 70, 200, 800, 70, 1, 3.5, 5, 70, 1.2, 6, 45, 1.5, and 60 in units of s/mm2 . Low b-values were much more frequent than high b-values. The optimized b-value distribution resulted in a higher fit stability compared to distributions used in literature in both, simulation and in vivo measurements. Using more than 6 b-values, ideally 16 or more, increased the fit stability considerably.Using optimized b-values, the fit uncertainty in triexponential IVIM can be largely reduced. Ideally, 16 or more b-values should be acquired.
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000165942 7001_ $$aMartin, Jan$$b1
000165942 7001_ $$aWetscherek, Andreas$$b2
000165942 7001_ $$0P:(DE-He78)59dfdd0ee0a7f0db81535f0781a3a6d6$$aKuder, Tristan Anselm$$b3$$udkfz
000165942 7001_ $$aUder, Michael$$b4
000165942 7001_ $$aHensel, Bernhard$$b5
000165942 7001_ $$aLaun, Frederik Bernd$$b6
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