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@ARTICLE{Riexinger:165942,
      author       = {A. Riexinger and J. Martin and A. Wetscherek and T. A.
                      Kuder$^*$ and M. Uder and B. Hensel and F. B. Laun},
      title        = {{A}n optimized b-value distribution for triexponential
                      intravoxel incoherent motion ({IVIM}) in the liver.},
      journal      = {Magnetic resonance in medicine},
      volume       = {85},
      number       = {4},
      issn         = {1522-2594},
      address      = {New York, NY [u.a.]},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2020-02493},
      pages        = {2095-2108},
      year         = {2021},
      note         = {2021 Apr;85(4):2095-2108},
      abstract     = {To find an optimized b-value distribution for reproducible
                      triexponential intravoxel incoherent motion (IVIM) exams in
                      the liver.A numeric optimization of b-value distributions
                      was performed using the triexponential IVIM equation and 27
                      different IVIM parameter sets. Starting with an initially
                      optimized distribution of 6 b-values, the number of b-values
                      was increased stepwise. Each new b-value was chosen from a
                      set of 64 predefined b-values based on the computed summed
                      relative mean error of the fitted triexponential IVIM
                      parameters. This process was repeated for up to 100
                      b-values. In simulations and in vivo measurements, optimized
                      b-value distributions were compared to 4 representative
                      distributions found in literature.The first 16 optimized
                      b-values were 0, 0.3, 0.3, 70, 200, 800, 70, 1, 3.5, 5, 70,
                      1.2, 6, 45, 1.5, and 60 in units of s/mm2 . Low b-values
                      were much more frequent than high b-values. The optimized
                      b-value distribution resulted in a higher fit stability
                      compared to distributions used in literature in both,
                      simulation and in vivo measurements. Using more than 6
                      b-values, ideally 16 or more, increased the fit stability
                      considerably.Using optimized b-values, the fit uncertainty
                      in triexponential IVIM can be largely reduced. Ideally, 16
                      or more b-values should be acquired.},
      cin          = {E020},
      ddc          = {610},
      cid          = {I:(DE-He78)E020-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33201549},
      doi          = {10.1002/mrm.28582},
      url          = {https://inrepo02.dkfz.de/record/165942},
}