TY  - JOUR
AU  - Escala-Garcia, Maria
AU  - Morra, Anna
AU  - Canisius, Sander
AU  - Chang-Claude, Jenny
AU  - Kar, Siddhartha
AU  - Zheng, Wei
AU  - Bojesen, Stig E
AU  - Easton, Doug
AU  - Pharoah, Paul D P
AU  - Schmidt, Marjanka K
TI  - Breast cancer risk factors and their effects on survival: a Mendelian randomisation study.
JO  - BMC medicine
VL  - 18
IS  - 1
SN  - 1741-7015
CY  - Heidelberg [u.a.]
PB  - Springer
M1  - DKFZ-2020-02496
SP  - 327
PY  - 2020
AB  - Observational studies have investigated the association of risk factors with breast cancer prognosis. However, the results have been conflicting and it has been challenging to establish causality due to potential residual confounding. Using a Mendelian randomisation (MR) approach, we aimed to examine the potential causal association between breast cancer-specific survival and nine established risk factors for breast cancer: alcohol consumption, body mass index, height, physical activity, mammographic density, age at menarche or menopause, smoking, and type 2 diabetes mellitus (T2DM).We conducted a two-sample MR analysis on data from the Breast Cancer Association Consortium (BCAC) and risk factor summary estimates from the GWAS Catalog. The BCAC data included 86,627 female patients of European ancestry with 7054 breast cancer-specific deaths during 15 years of follow-up. Of these, 59,378 were estrogen receptor (ER)-positive and 13,692 were ER-negative breast cancer patients. For the significant association, we used sensitivity analyses and a multivariable MR model. All risk factor associations were also examined in a model adjusted by other prognostic factors.Increased genetic liability to T2DM was significantly associated with worse breast cancer-specific survival (hazard ratio [HR] = 1.10, 95
LB  - PUB:(DE-HGF)16
C6  - pmid:33198768
DO  - DOI:10.1186/s12916-020-01797-2
UR  - https://inrepo02.dkfz.de/record/165945
ER  -