%0 Journal Article
%A Kaaks, Rudolf
%A Delorme, Stefan
%T Lung Cancer Screening by Low-Dose Computed Tomography - Part 1: Expected Benefits, Possible Harms, and Criteria for Eligibility and Population Targeting [Lungenkrebs-Screening mittels Niedrigdosis-Computertomografie – Teil 1: Erwarteter Nutzen, mögliche Schäden und Kriterien für die Eignung und das Targeting der Bevölkerung].
%J RöFo
%V 193
%N 5
%@ 1438-9010
%C Stuttgart [u.a.]
%I Thieme
%M DKFZ-2020-02513
%P 527-536
%D 2021
%Z #EA:C020#LA:E010#2021 May;193(5):527-536
%X Trials in the USA and Europe have convincingly demonstrated the efficacy of screening by low-dose computed tomography (LDCT) as a means to lower lung cancer mortality, but also document potential harms related to radiation, psychosocial stress, and invasive examinations triggered by false-positive screening tests and overdiagnosis. To ensure that benefits (lung cancer deaths averted; life years gained) outweigh the risk of harm, lung cancer screening should be targeted exclusively to individuals who have an elevated risk of lung cancer, plus sufficient residual life expectancy. Overall, randomized screening trials show an approximate 20 
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:33212540
%R 10.1055/a-1290-7926
%U https://inrepo02.dkfz.de/record/165964