TY  - JOUR
AU  - Rattay, Tim
AU  - Seibold, Petra
AU  - Aguado-Barrera, Miguel E
AU  - Altabas, Manuel
AU  - Azria, David
AU  - Barnett, Gillian C
AU  - Bultijnck, Renée
AU  - Chang-Claude, Jenny
AU  - Choudhury, Ananya
AU  - Coles, Charlotte E
AU  - Dunning, Alison M
AU  - Elliott, Rebecca M
AU  - Farcy Jacquet, Marie-Pierre
AU  - Gutiérrez-Enríquez, Sara
AU  - Johnson, Kerstie
AU  - Müller, Anusha
AU  - Post, Giselle
AU  - Rancati, Tiziana
AU  - Reyes, Victoria
AU  - Rosenstein, Barry S
AU  - De Ruysscher, Dirk
AU  - de Santis, Maria C
AU  - Sperk, Elena
AU  - Stobart, Hilary
AU  - Symonds, R Paul
AU  - Taboada-Valladares, Begoña
AU  - Vega, Ana
AU  - Veldeman, Liv
AU  - Webb, Adam J
AU  - West, Catharine M
AU  - Valdagni, Riccardo
AU  - Talbot, Christopher J
AU  - Lievens, Yolande
AU  - van Eijkeren, Marc
AU  - Ost, Piet
AU  - Fonteyne, Valérie
AU  - Monten, Christel
AU  - De Neve, Wilfried
AU  - Peeters, Stephanie
AU  - Haustermans, Karin
AU  - Weltens, Caroline
AU  - Defraene, Gilles
AU  - Lambrecht, Maarten
AU  - van Limberghen, Erik
AU  - Briers, Erik
AU  - Bourgier, Celine
AU  - Brengues, Muriel
AU  - Draghici, Roxana
AU  - Bons, Francoise
AU  - Blaschke, Thomas
AU  - Weiß, Christian
AU  - Helmbold, Irmgard
AU  - Weißenberger, Christian
AU  - Stegmaier, Petra
AU  - Claßen, Johannes
AU  - Giesche, Ulrich
AU  - Sautter-Bihl, Marie-Luise
AU  - Neu, Burkhard
AU  - Schnabel, Thomas
AU  - Ehmann, Michael
AU  - Gauter-Fleckenstein, Benjamin
AU  - Herskind, Carsten
AU  - Veldwijk, Marlon
AU  - Schäfer, Jörg
AU  - Giandini, Tommaso
AU  - Franceschini, Marzia
AU  - Sangalli, Claudia
AU  - Avuzzi, Barbara
AU  - Morlino, Sara
AU  - Lozza, Laura
AU  - Pietro, Gabriele
AU  - Delmastro, Elena
AU  - Garibaldi, Elisabetta
AU  - Cicchetti, Alessandro
AU  - Vanneste, Ben
AU  - Piqué-Leiva, Bibiana
AU  - Molla, Meritxel
AU  - Giraldo, Alexandra
AU  - Ramos, Monica
AU  - Lobato-Busto, Ramon
AU  - Sosa-Fajardo, Paloma
AU  - Moya, Laura Torrado
AU  - Dominguez-Rios, Isabel
AU  - Fajardo-Paneque, Irene
AU  - Calvo-Crespo, Patricia
AU  - Carballo, Ana
AU  - Peleteiro, Paula
AU  - Olivia-Fuentes-Rios
AU  - Gomez-Caamano, Antonio
AU  - Harrop, Victoria
AU  - Payne, Debbie
AU  - Keni, Manjusha
AU  - Lavers, Samuel
AU  - Wright, Simon
AU  - Thiagarajan, Sridhar
AU  - Aznar-Garcia, Luis
AU  - Kancherla, Kiran
AU  - Kent, Christopher
AU  - Vasanthan, Subramaniam
AU  - Appleton, Donna
AU  - Kaushik, Monika
AU  - Kenny, Frances
AU  - Khout, Hazem
AU  - Krupa, Jaroslaw
AU  - Lambert, Kelly V
AU  - Pilgrim, Simon
AU  - Shokuhi, Sheila
AU  - Valassiadou, Kalliope
AU  - Bioangiu, Ion
AU  - Sampson, Kufre
AU  - Osman, Ahmed
AU  - Faivre-Finn, Corinne
AU  - Foweraker, Karen
AU  - Pascoe, Abigail
AU  - Esler, Claire P
AU  - Ward, Tim
AU  - Higginson, Daniel S
AU  - Stock, Richard G
AU  - Green, Sheryl
TI  - External Validation of a Predictive Model for Acute Skin Radiation Toxicity in the REQUITE Breast Cohort.
JO  - Frontiers in oncology
VL  - 10
SN  - 2234-943X
CY  - Lausanne
PB  - Frontiers Media
M1  - DKFZ-2020-02524
SP  - 575909
PY  - 2020
AB  - Background: Acute skin toxicity is a common and usually transient side-effect of breast radiotherapy although, if sufficiently severe, it can affect breast cosmesis, aftercare costs and the patient's quality-of-life. The aim of this study was to develop predictive models for acute skin toxicity using published risk factors and externally validate the models in patients recruited into the prospective multi-center REQUITE (validating pREdictive models and biomarkers of radiotherapy toxicity to reduce side-effects and improve QUalITy of lifE in cancer survivors) study. Methods: Patient and treatment-related risk factors significantly associated with acute breast radiation toxicity on multivariate analysis were identified in the literature. These predictors were used to develop risk models for acute erythema and acute desquamation (skin loss) in three Radiogenomics Consortium cohorts of patients treated by breast-conserving surgery and whole breast external beam radiotherapy (n = 2,031). The models were externally validated in the REQUITE breast cancer cohort (n = 2,057). Results: The final risk model for acute erythema included BMI, breast size, hypo-fractionation, boost, tamoxifen use and smoking status. This model was validated in REQUITE with moderate discrimination (AUC 0.65), calibration and agreement between predicted and observed toxicity (Brier score 0.17). The risk model for acute desquamation, excluding the predictor tamoxifen use, failed to validate in the REQUITE cohort. Conclusions: While most published prediction research in the field has focused on model development, this study reports successful external validation of a predictive model using clinical risk factors for acute erythema following radiotherapy after breast-conserving surgery. This model retained discriminatory power but will benefit from further re-calibration. A similar model to predict acute desquamation failed to validate in the REQUITE cohort. Future improvements and more accurate predictions are expected through the addition of genetic markers and application of other modeling and machine learning techniques.
LB  - PUB:(DE-HGF)16
C6  - pmid:33216838
C2  - pmc:PMC7664984
DO  - DOI:10.3389/fonc.2020.575909
UR  - https://inrepo02.dkfz.de/record/165985
ER  -