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@ARTICLE{Thomsen:166049,
      author       = {H. Thomsen$^*$ and X. Li and K. Sundquist and J. Sundquist
                      and A. Försti$^*$ and K. Hemminki$^*$},
      title        = {{F}amilial associations for rheumatoid autoimmune
                      diseases.},
      journal      = {Rheumatology advances in practice},
      volume       = {4},
      number       = {2},
      issn         = {2514-1775},
      address      = {Oxford},
      publisher    = {Oxford University Press},
      reportid     = {DKFZ-2020-02588},
      pages        = {rkaa048},
      year         = {2020},
      note         = {#EA:C050#LA:C050#LA:C020#},
      abstract     = {Previous studies have shown a familial component in RA and
                      in some other rheumatic autoimmune diseases (RAIDs), but
                      because of the different study designs the risk estimates
                      for familial risks differ extensively. The objective of this
                      study is to identify familial components for RAIDs.We
                      collected data on patients diagnosed in Swedish hospitals
                      with RA, AS, PM/DM, SS, SLE and SSc (and scleroderma) and
                      calculated familial standardized incidence ratios (SIRs) for
                      each of these (concordant) and between them (discordant).The
                      combined number of RAID patients in the offspring population
                      (for whom SIRs were calculated) was 71 544, and in the
                      whole population the number was 152 714, accounting for
                      $19.8\%$ of all autoimmune diseases in Sweden. AS showed the
                      highest concordant familial risk of 18.42, followed by SLE
                      (14.04), SS (8.63), SSc (4.50), PM/DM (4.03) and RA (3.03).
                      There was no sex difference in SIRs. Risks for AS and SLE
                      were 80.28 and 19.53 for persons whose parents and siblings
                      were affected. Discordant risks were far lower than
                      concordant risks, but they were significant for RA with all
                      the other five RAIDs, for SLE and SSc with four RAIDs, for
                      AS and SS with three RAIDs and for PM/DM with two RAIDs,
                      attesting to extensive polyautoimmunity between RAIDs.The
                      derived familial risks in this nationwide family study on
                      medically diagnosed RAID are compatible with emerging
                      evidence on the polygenic background of these complex
                      diseases. Novel genetic pathways offer new therapeutic
                      targets that alleviate disease onset optimally in high-risk
                      familial patients and others.},
      cin          = {C050 / B062 / HD01 / C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C050-20160331 / I:(DE-He78)B062-20160331 /
                      I:(DE-He78)HD01-20160331 / I:(DE-He78)C020-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33241174},
      pmc          = {pmc:PMC7673201},
      doi          = {10.1093/rap/rkaa048},
      url          = {https://inrepo02.dkfz.de/record/166049},
}