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@ARTICLE{Rehm:166134,
      author       = {M. Rehm and G. Büchele and R. S. Peter and R. E. Brenner
                      and K.-P. Günther and H. Brenner$^*$ and W. Koenig and D.
                      Rothenbacher},
      title        = {{R}elationship between cardiac biomarker concentrations and
                      long-term mortality in subjects with osteoarthritis.},
      journal      = {PLOS ONE},
      volume       = {15},
      number       = {12},
      issn         = {1932-6203},
      address      = {San Francisco, California, US},
      publisher    = {PLOS},
      reportid     = {DKFZ-2020-02642},
      pages        = {e0242814 -},
      year         = {2020},
      abstract     = {Osteoarthritis (OA) is associated with adverse
                      cardio-metabolic features. N-terminal pro-B-type natriuretic
                      peptide (NT-proBNP) and high-sensitivity troponins T and I
                      (hs-cTnT and hs-cTnI) are well-characterized cardiac markers
                      and provide prognostic information. The objective was to
                      assess the association of cardiac biomarker concentrations
                      with long-term mortality in subjects with OA. In a cohort of
                      679 OA subjects, undergoing hip or knee replacement during
                      1995/1996, cardiac biomarkers were measured and subjects
                      were followed over 20 years. During a median follow-up of
                      18.4 years, 332 $(48.9\%)$ subjects died. Median of hs-cTnT,
                      hs-cTnI, and NT-proBNP at baseline was 3.2 ng/L, 3.9 ng/L,
                      and 96.8 ng/L. The top quartile of NT-proBNP was associated
                      with increased risk of mortality (Hazard Ratio (HR) 1.79,
                      $95\%$ confidence interval (CI) 1.17-2.73) after adjustment
                      for covariates including troponins (hs-cTnT HR 1.30 $(95\%$
                      CI 0.90-1.89), hs-cTnI HR 1.32 $(95\%$ CI 0.87-2.00) for top
                      category). When biomarker associations were evaluated as
                      continuous variables, only NT-proBNP (HR per log-unit
                      increment 1.34, $95\%$ CI 1.16-1.54) and hs-cTnI (HR 1.38,
                      $95\%$ CI 1.11-1.72) showed robust results. Elevated cardiac
                      biomarker concentrations predicted an increased risk of
                      long-term mortality and strongest for NT-proBNP and hs-cTnI.
                      These results might help to identify subjects at risk and
                      target preventive efforts early.},
      cin          = {HD01 / C070 / C120},
      ddc          = {610},
      cid          = {I:(DE-He78)HD01-20160331 / I:(DE-He78)C070-20160331 /
                      I:(DE-He78)C120-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33264342},
      doi          = {10.1371/journal.pone.0242814},
      url          = {https://inrepo02.dkfz.de/record/166134},
}