TY  - JOUR
AU  - Thomsen, Hauke
AU  - Li, Xinjun
AU  - Sundquist, Kristina
AU  - Sundquist, Jan
AU  - Försti, Asta
AU  - Hemminki, Kari
TI  - Familial risks between giant cell arteritis and Takayasu arteritis and other autoimmune diseases in the population of Sweden.
JO  - Scientific reports
VL  - 10
IS  - 1
SN  - 2045-2322
CY  - [London]
PB  - Macmillan Publishers Limited, part of Springer Nature
M1  - DKFZ-2020-02648
SP  - 20887
PY  - 2020
N1  - #EA:C050#LA:C050#LA:C020#
AB  - Giant cell arteritis (GCA, also called temporal arteritis) is a rare and Takayasu arteritis (TA) is an even rarer autoimmune disease (AID), both of which present with inflammatory vasculitis of large and medium size arteries. The risk factors are largely undefined but disease susceptibility has been associated with human leukocyte antigen locus. Population-level familial risk is not known. In the present nation-wide study we describe familial risk for GCA and for GCA and TA with any other AID based on the Swedish hospital diagnoses up to years 2012. Family relationships were obtained from the Multigeneration Register. Familial standardized incidence ratios (SIRs) were calculated for offspring whose parents or siblings were diagnosed with GCA, TA or any other AID. The number of GCA patients in the offspring generation was 4695, compared to 209 TA patients; for both, familial patients accounted for 1
LB  - PUB:(DE-HGF)16
C6  - pmid:33257751
DO  - DOI:10.1038/s41598-020-77857-7
UR  - https://inrepo02.dkfz.de/record/166140
ER  -