TY  - JOUR
AU  - Gao, Xin
AU  - Zhang, Yan
AU  - Boakye, Daniel
AU  - Li, Xiangwei
AU  - Chang-Claude, Jenny
AU  - Hoffmeister, Michael
AU  - Brenner, Hermann
TI  - Whole blood DNA methylation aging markers predict colorectal cancer survival: a prospective cohort study.
JO  - Clinical epigenetics
VL  - 12
IS  - 1
SN  - 1868-7083
CY  - [S.l.]
PB  - BioMed Central
M1  - DKFZ-2020-02649
SP  - 184
PY  - 2020
AB  - Blood DNA methylation-based aging algorithms predict mortality in the general population. We investigated the prognostic value of five established DNA methylation aging algorithms for patients with colorectal cancer (CRC).AgeAccelHorvath, AgeAccelHannum, DNAmMRscore, AgeAccelPheno and AgeAccelGrim were constructed using whole blood epi-genomic data from 2206 CRC patients. After a median follow-up of 6.2 years, 1079 deaths were documented, including 596 from CRC. Associations of the aging algorithms with survival outcomes were evaluated using the Cox regression and survival curves. Harrell's C-statistics were computed to investigate predictive performance.Adjusted hazard ratios (95
LB  - PUB:(DE-HGF)16
C6  - pmid:33256852
DO  - DOI:10.1186/s13148-020-00977-4
UR  - https://inrepo02.dkfz.de/record/166141
ER  -