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| Home > Publications database > Generation of biological hypotheses by functional imaging links tumor hypoxia to radiation induced tissue inflammation/glucose uptake in head and neck cancer. > print |
| 001 | 166144 | ||
| 005 | 20240229123221.0 | ||
| 024 | 7 | _ | |a 10.1016/j.radonc.2020.10.030 |2 doi |
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| 100 | 1 | _ | |a Zschaeck, Sebastian |0 P:(DE-HGF)0 |b 0 |
| 245 | _ | _ | |a Generation of biological hypotheses by functional imaging links tumor hypoxia to radiation induced tissue inflammation/glucose uptake in head and neck cancer. |
| 260 | _ | _ | |a Amsterdam [u.a.] |c 2020 |b Elsevier Science |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 520 | _ | _ | |a Positron emission tomography (PET) is a functional imaging modality which is able to deliver tracer specific biological information, e.g. about glucose uptake, inflammation or hypoxia of tumors. We performed a proof-of-principle study that used different tracers and expanded the analytical scope to non-tumor structures to evaluate tumor-host interactions.Based on a previously reported prospective imaging study on 50 patients treated with curative intent chemoradiation (CRT) for head and neck squamous cell carcinoma, PET-based hypoxia and normal tissue inflammation measured by repeat 18F-fluoromisonidazole (FMISO) PET and 18F-fluorodesoxyglucose (FDG) PET, respectively, were correlated using the Spearman correlation coefficient R. PET parameters determined before and during CRT (week 1, 2 and 5), were associated with local tumor control and overall survival.Tumor hypoxia at all measured times showed an inverse correlation with mid-treatment FDG-uptake of non-tumor affected oral (sub-)mucosa with R values between -0.35 and -0.6 (all p < 0.05). Mucosal FDG-uptake and mucosal hypoxia correlated positively but weaker (R values between 0.2 and 0.45). More tumor hypoxia in FMISO-PET (week 2) and less FDG-uptake of (sub-)mucosa in FDG-PET (week 4) were significantly associated with worse LC (FMISO TBRpeak: HR = 1.72, p = 0.030; FDG SUVmean: HR = 0.23, p = 0.025) and OS (FMISO TBRpeak: HR = 1.71, p = 0.007; FDG SUVmean: HR = 0.30, p = 0.003). Multivariable models including both parameters showed improved performance, suggesting that these modalities still bear distinct biological information despite their strong inter-correlation.We report first clinical evidence that tumor hypoxia is inversely correlated with increased FDG-uptake during radiation, potentially expressing inflammation. This observation merits further research and may have important implication for future research on tumor hypoxia and radio-immunology. Our study demonstrates that functional imaging can be utilized to assess complex tumor-host interactions and generate novel biological insights in vivo vero. |
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| 700 | 1 | _ | |a Zöphel, Klaus |0 P:(DE-HGF)0 |b 1 |
| 700 | 1 | _ | |a Seidlitz, Annekatrin |0 P:(DE-HGF)0 |b 2 |
| 700 | 1 | _ | |a Zips, Daniel |0 P:(DE-HGF)0 |b 3 |
| 700 | 1 | _ | |a Kotzerke, Jörg |0 P:(DE-HGF)0 |b 4 |
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| 700 | 1 | _ | |a Löck, Steffen |0 P:(DE-HGF)0 |b 7 |
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| 773 | _ | _ | |a 10.1016/j.radonc.2020.10.030 |g Vol. 155, p. 204 - 211 |0 PERI:(DE-600)1500707-8 |p 204 - 211 |t Radiotherapy and oncology |v 155 |y 2020 |x 0167-8140 |
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