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@MASTERSTHESIS{Camazzola:166145,
      author       = {G. Camazzola$^*$},
      title        = {{M}odulation of intracellular oxygen:making the cell
                      nucleus hypoxic forextracellular oxic conditions},
      school       = {Universität Heidelberg},
      type         = {Masterarbeit},
      reportid     = {DKFZ-2020-02653},
      year         = {2020},
      note         = {Masterarbeit, Universität Heidelberg, 2020},
      abstract     = {In the presented work the analysis of a novel molecular
                      mechanism is proposed, by whichcells can modulate their
                      intracellular oxygen and potentially become hypoxic,
                      inducingfavourable circumstances for metabolic
                      reprogramming, even under extracellular oxic conditions.
                      This phenomenon is based on the competition between O2
                      diffusion, from theextracellular environment to the nucleus,
                      and its consumption, especially by NOX enzymes.The novelty
                      revolves around the assumptions that the endoplasmic
                      reticulum (ER) membranes can lower the diffusion rate of
                      oxygen, and that the sensing enzymes become moreeffective at
                      removing O2for low values of the Michaelis constant KM.
                      After a preliminarystudy of oxygen concentration inside the
                      cell, an analysis of different factors affecting
                      thisphenomenon was carried out. Attention was given to the
                      Michaelis-Menten parametersVmax and KM, considering
                      consumption differences between ER and cytosol, the
                      extracellular oxygen, the number of membrane pairs, the
                      membrane porosity and the dependence onthe cell cycle phase.
                      A relation between porosity and number of membranes was
                      established,and the ratio of nuclear O2 of G1 phase relative
                      to S phase, for different KM, was determined. In conclusion,
                      the initial hypothesis has been confirmed, and some
                      experimentalresults obtained in previous studies have been
                      validated.},
      cin          = {E041},
      cid          = {I:(DE-He78)E041-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)19},
      url          = {https://inrepo02.dkfz.de/record/166145},
}