000166149 001__ 166149
000166149 005__ 20240229123221.0
000166149 037__ $$aDKFZ-2020-02657
000166149 1001_ $$0P:(DE-He78)0e877f4a0c1c0a7eef860eb713ef8804$$aMeles Freitas, Hugo Filipe$$b0$$udkfz
000166149 245__ $$aPrompt Gamma-RaySpectroscopy inProton Therapy forProstate Cancer
000166149 260__ $$c2020
000166149 3367_ $$2DataCite$$aOutput Types/Supervised Student Publication
000166149 3367_ $$02$$2EndNote$$aThesis
000166149 3367_ $$2BibTeX$$aMASTERSTHESIS
000166149 3367_ $$2DRIVER$$amasterThesis
000166149 3367_ $$0PUB:(DE-HGF)19$$2PUB:(DE-HGF)$$aMaster Thesis$$bmaster$$mmaster$$s1608295374_32213
000166149 3367_ $$2ORCID$$aSUPERVISED_STUDENT_PUBLICATION
000166149 502__ $$aMasterarbeit, University of Porto, 2020$$bMasterarbeit$$cUniversity of Porto$$gFaculty of physics
000166149 520__ $$aThe use of protons in radiotherapy has vastly increased in the last 10 years, becauseof the predicted lower toxicity from the radiation. However, the considerable uncertaintyin the positioning of the Bragg peak within the patient has lowered the efficacy of proton in treating prostate cancer tumours. Additionally, the treatment of prostate cancerpresents a significant sensitivity regarding interplay effects. To mitigate such effects, arectal balloon filled with water is often used in prostate cancer treatments. On the otherhand, prompt gamma-ray spectroscopy (PGS) in an emergent technique that makes useof prompt gamma-ray (PG) lines and its ratios to infer the range. The PG lines result fromnuclear reactions and are distinctive for each nuclide. This dissertation focus on the studyof PGS in proton therapy for prostate cancer. When analysed with PGS, water targetsbehaves like tissues. However, if the balloon is filled with a different solution, one canexpect a distinct PG spectrum. Exploiting the 1.78 MeV PG line of 28Si a novel applicationof PGS is presented. The application involves the use of a rectal balloon with a 28Si-basedsolution. Research using these balloons and a patient-like phantom was carried out. Thepresence of 28Si PG line on the energy spectra was quantified for different scenarios. Theresults show great potential for predicting single-spot proton range within the balloon.Thus, the technique has the potential of assessing complication in the rectum and allowsdoctors to use an alternative technique for prostate cancer (e.g., use of anterior/posteriorbeams).
000166149 536__ $$0G:(DE-HGF)POF3-315$$a315 - Imaging and radiooncology (POF3-315)$$cPOF3-315$$fPOF III$$x0
000166149 909CO $$ooai:inrepo02.dkfz.de:166149$$pVDB
000166149 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)0e877f4a0c1c0a7eef860eb713ef8804$$aDeutsches Krebsforschungszentrum$$b0$$kDKFZ
000166149 9131_ $$0G:(DE-HGF)POF3-315$$1G:(DE-HGF)POF3-310$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vImaging and radiooncology$$x0
000166149 9141_ $$y2020
000166149 9201_ $$0I:(DE-He78)E041-20160331$$kE041$$lE041 Medizinische Physik in der Radioonkologie$$x0
000166149 980__ $$amaster
000166149 980__ $$aVDB
000166149 980__ $$aI:(DE-He78)E041-20160331
000166149 980__ $$aUNRESTRICTED