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@MASTERSTHESIS{MelesFreitas:166149,
      author       = {H. F. Meles Freitas$^*$},
      title        = {{P}rompt {G}amma-{R}ay{S}pectroscopy in{P}roton {T}herapy
                      for{P}rostate {C}ancer},
      school       = {University of Porto},
      type         = {Masterarbeit},
      reportid     = {DKFZ-2020-02657},
      year         = {2020},
      note         = {Masterarbeit, University of Porto, 2020},
      abstract     = {The use of protons in radiotherapy has vastly increased in
                      the last 10 years, becauseof the predicted lower toxicity
                      from the radiation. However, the considerable uncertaintyin
                      the positioning of the Bragg peak within the patient has
                      lowered the efficacy of proton in treating prostate cancer
                      tumours. Additionally, the treatment of prostate
                      cancerpresents a significant sensitivity regarding interplay
                      effects. To mitigate such effects, arectal balloon filled
                      with water is often used in prostate cancer treatments. On
                      the otherhand, prompt gamma-ray spectroscopy (PGS) in an
                      emergent technique that makes useof prompt gamma-ray (PG)
                      lines and its ratios to infer the range. The PG lines result
                      fromnuclear reactions and are distinctive for each nuclide.
                      This dissertation focus on the studyof PGS in proton therapy
                      for prostate cancer. When analysed with PGS, water
                      targetsbehaves like tissues. However, if the balloon is
                      filled with a different solution, one canexpect a distinct
                      PG spectrum. Exploiting the 1.78 MeV PG line of 28Si a novel
                      applicationof PGS is presented. The application involves the
                      use of a rectal balloon with a 28Si-basedsolution. Research
                      using these balloons and a patient-like phantom was carried
                      out. Thepresence of 28Si PG line on the energy spectra was
                      quantified for different scenarios. Theresults show great
                      potential for predicting single-spot proton range within the
                      balloon.Thus, the technique has the potential of assessing
                      complication in the rectum and allowsdoctors to use an
                      alternative technique for prostate cancer (e.g., use of
                      anterior/posteriorbeams).},
      cin          = {E041},
      cid          = {I:(DE-He78)E041-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)19},
      url          = {https://inrepo02.dkfz.de/record/166149},
}