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| 001 | 166149 | ||
| 005 | 20240229123221.0 | ||
| 037 | _ | _ | |a DKFZ-2020-02657 |
| 100 | 1 | _ | |a Meles Freitas, Hugo Filipe |0 P:(DE-He78)0e877f4a0c1c0a7eef860eb713ef8804 |b 0 |u dkfz |
| 245 | _ | _ | |a Prompt Gamma-RaySpectroscopy inProton Therapy forProstate Cancer |
| 260 | _ | _ | |c 2020 |
| 336 | 7 | _ | |a Output Types/Supervised Student Publication |2 DataCite |
| 336 | 7 | _ | |a Thesis |0 2 |2 EndNote |
| 336 | 7 | _ | |a MASTERSTHESIS |2 BibTeX |
| 336 | 7 | _ | |a masterThesis |2 DRIVER |
| 336 | 7 | _ | |a Master Thesis |b master |m master |0 PUB:(DE-HGF)19 |s 1608295374_32213 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a SUPERVISED_STUDENT_PUBLICATION |2 ORCID |
| 502 | _ | _ | |a Masterarbeit, University of Porto, 2020 |c University of Porto |b Masterarbeit |g Faculty of physics |
| 520 | _ | _ | |a The use of protons in radiotherapy has vastly increased in the last 10 years, becauseof the predicted lower toxicity from the radiation. However, the considerable uncertaintyin the positioning of the Bragg peak within the patient has lowered the efficacy of proton in treating prostate cancer tumours. Additionally, the treatment of prostate cancerpresents a significant sensitivity regarding interplay effects. To mitigate such effects, arectal balloon filled with water is often used in prostate cancer treatments. On the otherhand, prompt gamma-ray spectroscopy (PGS) in an emergent technique that makes useof prompt gamma-ray (PG) lines and its ratios to infer the range. The PG lines result fromnuclear reactions and are distinctive for each nuclide. This dissertation focus on the studyof PGS in proton therapy for prostate cancer. When analysed with PGS, water targetsbehaves like tissues. However, if the balloon is filled with a different solution, one canexpect a distinct PG spectrum. Exploiting the 1.78 MeV PG line of 28Si a novel applicationof PGS is presented. The application involves the use of a rectal balloon with a 28Si-basedsolution. Research using these balloons and a patient-like phantom was carried out. Thepresence of 28Si PG line on the energy spectra was quantified for different scenarios. Theresults show great potential for predicting single-spot proton range within the balloon.Thus, the technique has the potential of assessing complication in the rectum and allowsdoctors to use an alternative technique for prostate cancer (e.g., use of anterior/posteriorbeams). |
| 536 | _ | _ | |a 315 - Imaging and radiooncology (POF3-315) |0 G:(DE-HGF)POF3-315 |c POF3-315 |f POF III |x 0 |
| 909 | C | O | |o oai:inrepo02.dkfz.de:166149 |p VDB |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 0 |6 P:(DE-He78)0e877f4a0c1c0a7eef860eb713ef8804 |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Krebsforschung |1 G:(DE-HGF)POF3-310 |0 G:(DE-HGF)POF3-315 |3 G:(DE-HGF)POF3 |2 G:(DE-HGF)POF3-300 |4 G:(DE-HGF)POF |v Imaging and radiooncology |x 0 |
| 914 | 1 | _ | |y 2020 |
| 920 | 1 | _ | |0 I:(DE-He78)E041-20160331 |k E041 |l E041 Medizinische Physik in der Radioonkologie |x 0 |
| 980 | _ | _ | |a master |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-He78)E041-20160331 |
| 980 | _ | _ | |a UNRESTRICTED |
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