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@MASTERSTHESIS{OchoaParra:166155,
      author       = {L. A. P. Ochoa Parra$^*$},
      title        = {{E}nd-to-end range prediction for heavier ion radiation
                      therapy based on {M}onte {C}arlo simulations},
      school       = {Universidad Nacional de Colombia},
      type         = {Masterarbeit},
      reportid     = {DKFZ-2020-02660},
      year         = {2020},
      note         = {Masterarbeit, Universidad Nacional de Colombia, 2020},
      abstract     = {: The presence of range uncertainties in charged particle
                      therapy with light ions (CPT)requires the employment of
                      safety margins during treatment planning. These
                      affecttreatment quality, not allowing to fully exploit the
                      dosimetric potential of CPT. CPT ischaracterized by an
                      escalation of the dose deposition towards the end of the
                      range of theprimary particles followed by a steep decrease
                      to a low-dose tail (Bragg Peak). Thedimension of the safety
                      margins can be reduced by adopting novel methods to verify
                      theprimary particle ranges in patients. Non-invasive in vivo
                      monitoring can be performed bydetecting secondary radiation
                      emitted from the patient after nuclear interactions of
                      thebeam with tissue. Among secondary radiation, the gamma
                      de-excitation of nuclei has thefavorable properties of an
                      instantaneous emission and a discrete energy spectrum,
                      whichallows performing range control through prompt gamma
                      spectroscopy (PGS). Recentstudies demonstrated the
                      capabilities of PGS for online range verification for
                      protonbeams. Along with the experimental developments, a
                      critical step towards the applicationof PGS for range
                      control during patient treatments is the implementation of
                      the promptgamma generation in a treatment planning system.
                      The comparison of the experimentaldata acquired during the
                      treatment to the predicted spectral features is the
                      fundamentalstep to achieve absolute range measurements in
                      vivo. The project aimed to obtain a fullyintegrated method
                      to perform end-to-end range predictions in anthropomorphic
                      phantoms.In the first stage, a Monte Carlo simulation was
                      conducted to obtain the values of thecross-section for 19
                      prompt gamma-ray lines from proton-nuclear interactions with
                      16 O and12-C. The central part of the project included the
                      implementation of the cross-sections inthe research
                      treatment planning system matRad.},
      cin          = {E041},
      cid          = {I:(DE-He78)E041-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)19},
      url          = {https://inrepo02.dkfz.de/record/166155},
}