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@ARTICLE{PerezCornago:166200,
      author       = {A. Perez-Cornago and F. L. Crowe and P. N. Appleby and K.
                      E. Bradbury and A. M. Wood and M. U. Jakobsen and L. Johnson
                      and C. Sacerdote and M. Steur and E. Weiderpass and A. M. L.
                      Würtz and T. Kühn$^*$ and V. Katzke$^*$ and A.
                      Trichopoulou and A. Karakatsani and C. La Vecchia and G.
                      Masala and R. Tumino and S. Panico and I. Sluijs and G.
                      Skeie and L. Imaz and D. Petrova and J. R. Quirós and S. M.
                      C. Yohar and P. Jakszyn and O. Melander and E. Sonestedt and
                      J. Andersson and M. Wennberg and D. Aune and E. Riboli and
                      M. B. Schulze and E. di Angelantonio and N. J. Wareham and
                      J. Danesh and N. G. Forouhi and A. S. Butterworth and T. J.
                      Key},
      title        = {{P}lant foods, dietary fibre and risk of ischaemic heart
                      disease in the {E}uropean prospective investigation into
                      cancer and nutrition ({EPIC}) cohort.},
      journal      = {International journal of epidemiology},
      volume       = {50},
      number       = {1},
      issn         = {1464-3685},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {DKFZ-2020-02702},
      pages        = {212-222},
      year         = {2021},
      note         = {2021 Mar 3;50(1):212-222},
      abstract     = {Epidemiological evidence indicates that diets rich in plant
                      foods are associated with a lower risk of ischaemic heart
                      disease (IHD), but there is sparse information on fruit and
                      vegetable subtypes and sources of dietary fibre. This study
                      examined the associations of major plant foods, their
                      subtypes and dietary fibre with risk of IHD in the European
                      Prospective Investigation into Cancer and Nutrition
                      (EPIC).We conducted a prospective analysis of 490 311 men
                      and women without a history of myocardial infarction or
                      stroke at recruitment (12.6 years of follow-up, n cases =
                      8504), in 10 European countries. Dietary intake was assessed
                      using validated questionnaires, calibrated with 24-h
                      recalls. Multivariable Cox regressions were used to estimate
                      hazard ratios (HR) of IHD.There was a lower risk of IHD with
                      a higher intake of fruit and vegetables combined [HR per 200
                      g/day higher intake 0.94, $95\%$ confidence interval (CI):
                      0.90-0.99, P-trend = 0.009], and with total fruits (per 100
                      g/day 0.97, 0.95-1.00, P-trend = 0.021). There was no
                      evidence for a reduced risk for fruit subtypes, except for
                      bananas. Risk was lower with higher intakes of nuts and
                      seeds (per 10 g/day 0.90, 0.82-0.98, P-trend = 0.020), total
                      fibre (per 10 g/day 0.91, 0.85-0.98, P-trend = 0.015), fruit
                      and vegetable fibre (per 4 g/day 0.95, 0.91-0.99, P-trend =
                      0.022) and fruit fibre (per 2 g/day 0.97, 0.95-1.00, P-trend
                      = 0.045). No associations were observed between vegetables,
                      vegetables subtypes, legumes, cereals and IHD risk.In this
                      large prospective study, we found some small inverse
                      associations between plant foods and IHD risk, with fruit
                      and vegetables combined being the most strongly inversely
                      associated with risk. Whether these small associations are
                      causal remains unclear.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33245137},
      doi          = {10.1093/ije/dyaa155},
      url          = {https://inrepo02.dkfz.de/record/166200},
}