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@ARTICLE{Hoffmann:166295,
      author       = {I. Hoffmann$^*$},
      title        = {{C}entrosomes in mitotic spindle assembly and orientation.},
      journal      = {Current opinion in structural biology},
      volume       = {66},
      issn         = {0959-440X},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2020-02788},
      pages        = {193 - 198},
      year         = {2020},
      note         = {#LA:F045#},
      abstract     = {The centrosome is present in most animal cells and
                      functions as the major microtubule-organizing center to
                      ensure faithful chromosome segregation during cell division.
                      As cells transition from interphase to mitosis, the
                      duplicated centrosomes separate and move to opposite sides
                      of the cell where the spindle assembles. Centrosomes not
                      only nucleate but also organize microtubules of the mitotic
                      spindle. The mitotic spindle is anchored to the cell cortex
                      by the astral microtubules emanating from the centrosomes.
                      Proper orientation of the mitotic spindle is essential for
                      correct cell division. Centrosome-localized polo-like kinase
                      Plk1 has been linked to regulation of proper spindle
                      orientation. A number of proteins including MISP and NuMA
                      have been implicated in the Plk1-mediated spindle
                      orientation pathway.},
      subtyp        = {Review Article},
      cin          = {F045},
      ddc          = {570},
      cid          = {I:(DE-He78)F045-20160331},
      pnm          = {316 - Infections and cancer (POF3-316)},
      pid          = {G:(DE-HGF)POF3-316},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33296732},
      doi          = {10.1016/j.sbi.2020.11.003},
      url          = {https://inrepo02.dkfz.de/record/166295},
}