%0 Journal Article
%A Adolph, Jonas E
%A Fleischhack, Gudrun
%A Mikasch, Ruth
%A Zeller, Julia
%A Warmuth-Metz, Monika
%A Bison, Brigitte
%A Mynarek, Martin
%A Rutkowski, Stefan
%A Schüller, Ulrich
%A von Hoff, Katja
%A Obrecht, Denise
%A Pietsch, Torsten
%A Pfister, Stefan M
%A Pajtler, Kristian W
%A Witt, Olaf
%A Witt, Hendrik
%A Kortmann, Rolf-Dieter
%A Timmermann, Beate
%A Krauß, Jürgen
%A Frühwald, Michael C
%A Faldum, Andreas
%A Kwiecien, Robert
%A Bode, Udo
%A Tippelt, Stephan
%T Local and Systemic Therapy of Recurrent Ependymoma in Children and Adolescents: Short- and Long-term Results of the E-HIT-REZ 2005 Study.
%J Neuro-Oncology
%V 23
%N 6
%@ 1523-5866
%C Oxford
%I Oxford Univ. Press
%M DKFZ-2020-02949
%P 1012-1023
%D 2021
%Z 2021 Jun 1;23(6):1012-1023
%X Survival in recurrent ependymomas in children and adolescents mainly depends on the extent of resection. Studies on repeated radiotherapy and chemotherapy at relapse have shown conflicting results.Using data from the German multi-center E-HIT-REZ-2005 study, we examined the role of local therapy and the efficacy of chemotherapy with blockwise temozolomide (TMZ) in children and adolescents with recurrent ependymomas.53 patients with a median age of 6.9 years (1.25-25.4) at 1 st recurrence and a median follow-up time of 36 months (2-115) were recruited. Gross and near total resection (GTR/NTR) were achieved in 34 (64.2
%K chemotherapy (Other)
%K ependymoma (Other)
%K radiotherapy (Other)
%K relapse (Other)
%K tumor resection (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:33331885
%R 10.1093/neuonc/noaa276
%U https://inrepo02.dkfz.de/record/166506