%0 Journal Article
%A Bull, Caroline J
%A Bell, Joshua A
%A Murphy, Neil
%A Sanderson, Eleanor
%A Davey Smith, George
%A Timpson, Nicholas J
%A Banbury, Barbara L
%A Albanes, Demetrius
%A Berndt, Sonja I
%A Bézieau, Stéphane
%A Bishop, D Timothy
%A Brenner, Hermann
%A Buchanan, Daniel D
%A Burnett-Hartman, Andrea
%A Casey, Graham
%A Castellví-Bel, Sergi
%A Chan, Andrew T
%A Chang-Claude, Jenny
%A Cross, Amanda J
%A de la Chapelle, Albert
%A Figueiredo, Jane C
%A Gallinger, Steven J
%A Gapstur, Susan M
%A Giles, Graham G
%A Gruber, Stephen B
%A Gsur, Andrea
%A Hampe, Jochen
%A Hampel, Heather
%A Harrison, Tabitha A
%A Hoffmeister, Michael
%A Hsu, Li
%A Huang, Wen-Yi
%A Huyghe, Jeroen R
%A Jenkins, Mark A
%A Joshu, Corinne E
%A Keku, Temitope O
%A Kühn, Tilman
%A Kweon, Sun-Seog
%A Le Marchand, Loic
%A Li, Christopher I
%A Li, Li
%A Lindblom, Annika
%A Martín, Vicente
%A May, Anne M
%A Milne, Roger L
%A Moreno, Victor
%A Newcomb, Polly A
%A Offit, Kenneth
%A Ogino, Shuji
%A Phipps, Amanda I
%A Platz, Elizabeth A
%A Potter, John D
%A Qu, Conghui
%A Quirós, J Ramón
%A Rennert, Gad
%A Riboli, Elio
%A Sakoda, Lori C
%A Schafmayer, Clemens
%A Schoen, Robert E
%A Slattery, Martha L
%A Tangen, Catherine M
%A Tsilidis, Kostas K
%A Ulrich, Cornelia M
%A van Duijnhoven, Fränzel J B
%A van Guelpen, Bethany
%A Visvanathan, Kala
%A Vodicka, Pavel
%A Vodickova, Ludmila
%A Wang, Hansong
%A White, Emily
%A Wolk, Alicja
%A Woods, Michael O
%A Wu, Anna H
%A Campbell, Peter T
%A Zheng, Wei
%A Peters, Ulrike
%A Vincent, Emma E
%A Gunter, Marc J
%T Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study.
%J BMC medicine
%V 18
%N 1
%@ 1741-7015
%C Heidelberg [u.a.]
%I Springer
%M DKFZ-2020-02962
%P 396
%D 2020
%Z 2020 Dec 17;18(1):396
%X Higher adiposity increases the risk of colorectal cancer (CRC), but whether this relationship varies by anatomical sub-site or by sex is unclear. Further, the metabolic alterations mediating the effects of adiposity on CRC are not fully understood.We examined sex- and site-specific associations of adiposity with CRC risk and whether adiposity-associated metabolites explain the associations of adiposity with CRC. Genetic variants from genome-wide association studies of body mass index (BMI) and waist-to-hip ratio (WHR, unadjusted for BMI; N = 806,810), and 123 metabolites from targeted nuclear magnetic resonance metabolomics (N = 24,925), were used as instruments. Sex-combined and sex-specific Mendelian randomization (MR) was conducted for BMI and WHR with CRC risk (58,221 cases and 67,694 controls in the Genetics and Epidemiology of Colorectal Cancer Consortium, Colorectal Cancer Transdisciplinary Study, and Colon Cancer Family Registry). Sex-combined MR was conducted for BMI and WHR with metabolites, for metabolites with CRC, and for BMI and WHR with CRC adjusted for metabolite classes in multivariable models.In sex-specific MR analyses, higher BMI (per 4.2 kg/m2) was associated with 1.23 (95
%K Body mass index (Other)
%K CCFR (Other)
%K CORECT (Other)
%K Colorectal cancer (Other)
%K Epidemiology (Other)
%K GECCO (Other)
%K Mendelian randomization (Other)
%K Metabolism (Other)
%K NMR (Other)
%K Waist-to-hip ratio (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:33327948
%2 pmc:PMC7745469
%R 10.1186/s12916-020-01855-9
%U https://inrepo02.dkfz.de/record/166519