TY  - JOUR
AU  - Bull, Caroline J
AU  - Bell, Joshua A
AU  - Murphy, Neil
AU  - Sanderson, Eleanor
AU  - Davey Smith, George
AU  - Timpson, Nicholas J
AU  - Banbury, Barbara L
AU  - Albanes, Demetrius
AU  - Berndt, Sonja I
AU  - Bézieau, Stéphane
AU  - Bishop, D Timothy
AU  - Brenner, Hermann
AU  - Buchanan, Daniel D
AU  - Burnett-Hartman, Andrea
AU  - Casey, Graham
AU  - Castellví-Bel, Sergi
AU  - Chan, Andrew T
AU  - Chang-Claude, Jenny
AU  - Cross, Amanda J
AU  - de la Chapelle, Albert
AU  - Figueiredo, Jane C
AU  - Gallinger, Steven J
AU  - Gapstur, Susan M
AU  - Giles, Graham G
AU  - Gruber, Stephen B
AU  - Gsur, Andrea
AU  - Hampe, Jochen
AU  - Hampel, Heather
AU  - Harrison, Tabitha A
AU  - Hoffmeister, Michael
AU  - Hsu, Li
AU  - Huang, Wen-Yi
AU  - Huyghe, Jeroen R
AU  - Jenkins, Mark A
AU  - Joshu, Corinne E
AU  - Keku, Temitope O
AU  - Kühn, Tilman
AU  - Kweon, Sun-Seog
AU  - Le Marchand, Loic
AU  - Li, Christopher I
AU  - Li, Li
AU  - Lindblom, Annika
AU  - Martín, Vicente
AU  - May, Anne M
AU  - Milne, Roger L
AU  - Moreno, Victor
AU  - Newcomb, Polly A
AU  - Offit, Kenneth
AU  - Ogino, Shuji
AU  - Phipps, Amanda I
AU  - Platz, Elizabeth A
AU  - Potter, John D
AU  - Qu, Conghui
AU  - Quirós, J Ramón
AU  - Rennert, Gad
AU  - Riboli, Elio
AU  - Sakoda, Lori C
AU  - Schafmayer, Clemens
AU  - Schoen, Robert E
AU  - Slattery, Martha L
AU  - Tangen, Catherine M
AU  - Tsilidis, Kostas K
AU  - Ulrich, Cornelia M
AU  - van Duijnhoven, Fränzel J B
AU  - van Guelpen, Bethany
AU  - Visvanathan, Kala
AU  - Vodicka, Pavel
AU  - Vodickova, Ludmila
AU  - Wang, Hansong
AU  - White, Emily
AU  - Wolk, Alicja
AU  - Woods, Michael O
AU  - Wu, Anna H
AU  - Campbell, Peter T
AU  - Zheng, Wei
AU  - Peters, Ulrike
AU  - Vincent, Emma E
AU  - Gunter, Marc J
TI  - Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study.
JO  - BMC medicine
VL  - 18
IS  - 1
SN  - 1741-7015
CY  - Heidelberg [u.a.]
PB  - Springer
M1  - DKFZ-2020-02962
SP  - 396
PY  - 2020
N1  - 2020 Dec 17;18(1):396
AB  - Higher adiposity increases the risk of colorectal cancer (CRC), but whether this relationship varies by anatomical sub-site or by sex is unclear. Further, the metabolic alterations mediating the effects of adiposity on CRC are not fully understood.We examined sex- and site-specific associations of adiposity with CRC risk and whether adiposity-associated metabolites explain the associations of adiposity with CRC. Genetic variants from genome-wide association studies of body mass index (BMI) and waist-to-hip ratio (WHR, unadjusted for BMI; N = 806,810), and 123 metabolites from targeted nuclear magnetic resonance metabolomics (N = 24,925), were used as instruments. Sex-combined and sex-specific Mendelian randomization (MR) was conducted for BMI and WHR with CRC risk (58,221 cases and 67,694 controls in the Genetics and Epidemiology of Colorectal Cancer Consortium, Colorectal Cancer Transdisciplinary Study, and Colon Cancer Family Registry). Sex-combined MR was conducted for BMI and WHR with metabolites, for metabolites with CRC, and for BMI and WHR with CRC adjusted for metabolite classes in multivariable models.In sex-specific MR analyses, higher BMI (per 4.2 kg/m2) was associated with 1.23 (95
KW  - Body mass index (Other)
KW  - CCFR (Other)
KW  - CORECT (Other)
KW  - Colorectal cancer (Other)
KW  - Epidemiology (Other)
KW  - GECCO (Other)
KW  - Mendelian randomization (Other)
KW  - Metabolism (Other)
KW  - NMR (Other)
KW  - Waist-to-hip ratio (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:33327948
C2  - pmc:PMC7745469
DO  - DOI:10.1186/s12916-020-01855-9
UR  - https://inrepo02.dkfz.de/record/166519
ER  -