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@ARTICLE{Wu:166524,
      author       = {Y. Wu$^*$ and M. Fletcher$^*$ and Z. Gu$^*$ and Q. Wang$^*$
                      and B. M. Costa$^*$ and A. Bertoni$^*$ and K. H. Man$^*$ and
                      M. Schlotter$^*$ and J. Felsberg and J. Mangei$^*$ and M.
                      Barbus$^*$ and A.-C. Gaupel$^*$ and W. Wang$^*$ and T. Weiss
                      and R. Eils$^*$ and M. Weller and H. Liu$^*$ and G.
                      Reifenberger$^*$ and A. Korshunov$^*$ and P. Angel$^*$ and
                      P. Lichter$^*$ and C. Herrmann and B. Radlwimmer$^*$},
      title        = {{G}lioblastoma epigenome profiling identifies {SOX}10 as a
                      master regulator of molecular tumour subtype.},
      journal      = {Nature Communications},
      volume       = {11},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {DKFZ-2020-02967},
      pages        = {6434},
      year         = {2020},
      note         = {#EA:B060#EA:B086#LA:B060# / DKFZ-ZMBH Alliance},
      abstract     = {Glioblastoma frequently exhibits therapy-associated subtype
                      transitions to mesenchymal phenotypes with adverse
                      prognosis. Here, we perform multi-omic profiling of 60
                      glioblastoma primary tumours and use orthogonal analysis of
                      chromatin and RNA-derived gene regulatory networks to
                      identify 38 subtype master regulators, whose cell
                      population-specific activities we further map in published
                      single-cell RNA sequencing data. These analyses identify the
                      oligodendrocyte precursor marker and chromatin modifier
                      SOX10 as a master regulator in RTK I-subtype tumours. In
                      vitro functional studies demonstrate that SOX10 loss causes
                      a subtype switch analogous to the proneural-mesenchymal
                      transition observed in patients at the transcriptomic,
                      epigenetic and phenotypic levels. SOX10 repression in an in
                      vivo syngeneic graft glioblastoma mouse model results in
                      increased tumour invasion, immune cell infiltration and
                      significantly reduced survival, reminiscent of progressive
                      human glioblastoma. These results identify SOX10 as a bona
                      fide master regulator of the RTK I subtype, with both tumour
                      cell-intrinsic and microenvironmental effects.},
      cin          = {B060 / B086 / A100 / ED01 / A240 / B300},
      ddc          = {500},
      cid          = {I:(DE-He78)B060-20160331 / I:(DE-He78)B086-20160331 /
                      I:(DE-He78)A100-20160331 / I:(DE-He78)ED01-20160331 /
                      I:(DE-He78)A240-20160331 / I:(DE-He78)B300-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33339831},
      doi          = {10.1038/s41467-020-20225-w},
      url          = {https://inrepo02.dkfz.de/record/166524},
}