%0 Journal Article
%A Heisser, Thomas
%A Hoffmeister, Michael
%A Brenner, Hermann
%T Effects of Screening for Colorectal Cancer: Development, Documentation and Validation of a Multistate Markov Model.
%J International journal of cancer
%V 148
%N 8
%@ 1097-0215
%C Bognor Regis
%I Wiley-Liss
%M DKFZ-2020-02983
%P 1973-1981
%D 2021
%Z 2021 Apr 15;148(8):1973-1981#EA:C070#LA:C070#
%X Simulation models are a powerful tool to overcome gaps of evidence needed to inform medical decision making. Here, we present development and application of a multistate Markov model to simulate effects of colorectal cancer (CRC) screening, along with a thorough assessment of the model's ability to reproduce real-life outcomes. Firstly, we provide a comprehensive documentation of the model development, structure and assumptions. Secondly, to assess the model's external validity, we compared model-derived cumulative incidence and prevalences of colorectal neoplasms to (1) results from KolosSal, a study in German screening colonoscopy participants, (2) registry-based estimates of CRC incidence in Germany, and (3) outcome patterns of randomized sigmoidoscopy screening studies. We found that (1) more than 90
%K colorectal cancer (Other)
%K modelling (Other)
%K screening (Other)
%K validation (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:33320964
%R 10.1002/ijc.33437
%U https://inrepo02.dkfz.de/record/166540