TY  - JOUR
AU  - Heisser, Thomas
AU  - Hoffmeister, Michael
AU  - Brenner, Hermann
TI  - Effects of Screening for Colorectal Cancer: Development, Documentation and Validation of a Multistate Markov Model.
JO  - International journal of cancer
VL  - 148
IS  - 8
SN  - 1097-0215
CY  - Bognor Regis
PB  - Wiley-Liss
M1  - DKFZ-2020-02983
SP  - 1973-1981
PY  - 2021
N1  - 2021 Apr 15;148(8):1973-1981#EA:C070#LA:C070#
AB  - Simulation models are a powerful tool to overcome gaps of evidence needed to inform medical decision making. Here, we present development and application of a multistate Markov model to simulate effects of colorectal cancer (CRC) screening, along with a thorough assessment of the model's ability to reproduce real-life outcomes. Firstly, we provide a comprehensive documentation of the model development, structure and assumptions. Secondly, to assess the model's external validity, we compared model-derived cumulative incidence and prevalences of colorectal neoplasms to (1) results from KolosSal, a study in German screening colonoscopy participants, (2) registry-based estimates of CRC incidence in Germany, and (3) outcome patterns of randomized sigmoidoscopy screening studies. We found that (1) more than 90
KW  - colorectal cancer (Other)
KW  - modelling (Other)
KW  - screening (Other)
KW  - validation (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:33320964
DO  - DOI:10.1002/ijc.33437
UR  - https://inrepo02.dkfz.de/record/166540
ER  -