%0 Journal Article %A Löfvenborg, Josefin E %A Carlsson, Sofia %A Andersson, Tomas %A Hampe, Christiane S %A Koulman, Albert %A Chirlaque Lopez, María Dolores %A Jakszyn, Paula %A Katzke, Verena A %A Kühn, Tilman %A Kyrø, Cecilie %A Masala, Giovanna %A Nilsson, Peter M %A Overvad, Kim %A Panico, Salvatore %A Sánchez, Maria-Jose %A van der Schouw, Yvonne %A Schulze, Matthias B %A Tjønneland, Anne %A Weiderpass, Elisabete %A Riboli, Elio %A Forouhi, Nita G %A Sharp, Stephen J %A Rolandsson, Olov %A Wareham, Nicholas J %T Interaction Between GAD65 Antibodies and Dietary Fish Intake or Plasma Phospholipid n-3 Polyunsaturated Fatty Acids on Incident Adult-Onset Diabetes: The EPIC-InterAct Study. %J Diabetes care %V 44 %N 2 %@ 1935-5548 %C Alexandria, Va. %I Assoc. %M DKFZ-2020-03012 %P 416-424 %D 2021 %Z 2021 Feb;44(2):416-424 %X Islet autoimmunity is associated with diabetes incidence. We investigated whether there was an interaction between dietary fish intake or plasma phospholipid n-3 polyunsaturated fatty acid (PUFA) concentration with the 65-kDa isoform of GAD (GAD65) antibody positivity on the risk of developing adult-onset diabetes.We used prospective data on 11,247 incident cases of adult-onset diabetes and 14,288 noncases from the EPIC-InterAct case-cohort study conducted in eight European countries. Baseline plasma samples were analyzed for GAD65 antibodies and phospholipid n-3 PUFAs. Adjusted hazard ratios (HRs) for incident diabetes in relation to GAD65 antibody status and tertiles of plasma phospholipid n-3 PUFA or fish intake were estimated using Prentice-weighted Cox regression. Additive (proportion attributable to interaction [AP]) and multiplicative interactions between GAD65 antibody positivity (≥65 units/mL) and low fish/n-3 PUFA were assessed.The hazard of diabetes in antibody-positive individuals with low intake of total and fatty fish, respectively, was significantly elevated (HR 2.52 [95 %F PUB:(DE-HGF)16 %9 Journal Article %$ pmid:33303636 %R 10.2337/dc20-1463 %U https://inrepo02.dkfz.de/record/166569