%0 Journal Article
%A Löfvenborg, Josefin E
%A Carlsson, Sofia
%A Andersson, Tomas
%A Hampe, Christiane S
%A Koulman, Albert
%A Chirlaque Lopez, María Dolores
%A Jakszyn, Paula
%A Katzke, Verena A
%A Kühn, Tilman
%A Kyrø, Cecilie
%A Masala, Giovanna
%A Nilsson, Peter M
%A Overvad, Kim
%A Panico, Salvatore
%A Sánchez, Maria-Jose
%A van der Schouw, Yvonne
%A Schulze, Matthias B
%A Tjønneland, Anne
%A Weiderpass, Elisabete
%A Riboli, Elio
%A Forouhi, Nita G
%A Sharp, Stephen J
%A Rolandsson, Olov
%A Wareham, Nicholas J
%T Interaction Between GAD65 Antibodies and Dietary Fish Intake or Plasma Phospholipid n-3 Polyunsaturated Fatty Acids on Incident Adult-Onset Diabetes: The EPIC-InterAct Study.
%J Diabetes care
%V 44
%N 2
%@ 1935-5548
%C Alexandria, Va.
%I Assoc.
%M DKFZ-2020-03012
%P 416-424
%D 2021
%Z 2021 Feb;44(2):416-424
%X Islet autoimmunity is associated with diabetes incidence. We investigated whether there was an interaction between dietary fish intake or plasma phospholipid n-3 polyunsaturated fatty acid (PUFA) concentration with the 65-kDa isoform of GAD (GAD65) antibody positivity on the risk of developing adult-onset diabetes.We used prospective data on 11,247 incident cases of adult-onset diabetes and 14,288 noncases from the EPIC-InterAct case-cohort study conducted in eight European countries. Baseline plasma samples were analyzed for GAD65 antibodies and phospholipid n-3 PUFAs. Adjusted hazard ratios (HRs) for incident diabetes in relation to GAD65 antibody status and tertiles of plasma phospholipid n-3 PUFA or fish intake were estimated using Prentice-weighted Cox regression. Additive (proportion attributable to interaction [AP]) and multiplicative interactions between GAD65 antibody positivity (≥65 units/mL) and low fish/n-3 PUFA were assessed.The hazard of diabetes in antibody-positive individuals with low intake of total and fatty fish, respectively, was significantly elevated (HR 2.52 [95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:33303636
%R 10.2337/dc20-1463
%U https://inrepo02.dkfz.de/record/166569