TY  - JOUR
AU  - Löfvenborg, Josefin E
AU  - Carlsson, Sofia
AU  - Andersson, Tomas
AU  - Hampe, Christiane S
AU  - Koulman, Albert
AU  - Chirlaque Lopez, María Dolores
AU  - Jakszyn, Paula
AU  - Katzke, Verena A
AU  - Kühn, Tilman
AU  - Kyrø, Cecilie
AU  - Masala, Giovanna
AU  - Nilsson, Peter M
AU  - Overvad, Kim
AU  - Panico, Salvatore
AU  - Sánchez, Maria-Jose
AU  - van der Schouw, Yvonne
AU  - Schulze, Matthias B
AU  - Tjønneland, Anne
AU  - Weiderpass, Elisabete
AU  - Riboli, Elio
AU  - Forouhi, Nita G
AU  - Sharp, Stephen J
AU  - Rolandsson, Olov
AU  - Wareham, Nicholas J
TI  - Interaction Between GAD65 Antibodies and Dietary Fish Intake or Plasma Phospholipid n-3 Polyunsaturated Fatty Acids on Incident Adult-Onset Diabetes: The EPIC-InterAct Study.
JO  - Diabetes care
VL  - 44
IS  - 2
SN  - 1935-5548
CY  - Alexandria, Va.
PB  - Assoc.
M1  - DKFZ-2020-03012
SP  - 416-424
PY  - 2021
N1  - 2021 Feb;44(2):416-424
AB  - Islet autoimmunity is associated with diabetes incidence. We investigated whether there was an interaction between dietary fish intake or plasma phospholipid n-3 polyunsaturated fatty acid (PUFA) concentration with the 65-kDa isoform of GAD (GAD65) antibody positivity on the risk of developing adult-onset diabetes.We used prospective data on 11,247 incident cases of adult-onset diabetes and 14,288 noncases from the EPIC-InterAct case-cohort study conducted in eight European countries. Baseline plasma samples were analyzed for GAD65 antibodies and phospholipid n-3 PUFAs. Adjusted hazard ratios (HRs) for incident diabetes in relation to GAD65 antibody status and tertiles of plasma phospholipid n-3 PUFA or fish intake were estimated using Prentice-weighted Cox regression. Additive (proportion attributable to interaction [AP]) and multiplicative interactions between GAD65 antibody positivity (≥65 units/mL) and low fish/n-3 PUFA were assessed.The hazard of diabetes in antibody-positive individuals with low intake of total and fatty fish, respectively, was significantly elevated (HR 2.52 [95
LB  - PUB:(DE-HGF)16
C6  - pmid:33303636
DO  - DOI:10.2337/dc20-1463
UR  - https://inrepo02.dkfz.de/record/166569
ER  -