%0 Journal Article
%A Hoegen, Philipp
%A Lang, Clemens
%A Akbaba, Sati
%A Häring, Peter
%A Splinter, Mona
%A Miltner, Annette
%A Bachmann, Marion
%A Stahl-Arnsberger, Christiane
%A Brechter, Thomas
%A El Shafie, Rami A
%A Weykamp, Fabian
%A König, Laila
%A Debus, Jürgen
%A Hörner-Rieber, Juliane
%T Cone-Beam-CT Guided Adaptive Radiotherapy for Locally Advanced Non-small Cell Lung Cancer Enables Quality Assurance and Superior Sparing of Healthy Lung.
%J Frontiers in oncology
%V 10
%@ 2234-943X
%C Lausanne
%I Frontiers Media
%M DKFZ-2020-03045
%P 564857
%D 2020
%Z #EA:E050#LA:E050#
%X To evaluate the potential of cone-beam-CT (CB-CT) guided adaptive radiotherapy (ART) for locally advanced non-small cell lung cancer (NSCLC) for sparing of surrounding organs-at-risk (OAR).In 10 patients with locally advanced NSCLC, daily CB-CT imaging was acquired during radio- (n = 4) or radiochemotherapy (n = 6) for simulation of ART. Patients were treated with conventionally fractionated intensity-modulated radiotherapy (IMRT) with total doses of 60-66 Gy (pPlan) (311 fraction CB-CTs). OAR were segmented on every daily CB-CT and the tumor volumes were modified weekly depending on tumor changes. Doses actually delivered were recalculated on daily images (dPlan), and voxel-wise dose accumulation was performed using a deformable registration algorithm. For simulation of ART, treatment plans were adapted using the new contours and re-optimized weekly (aPlan).CB-CT showed continuous tumor regression of 1.1 ± 0.4
%K adaptive radiotherapy (Other)
%K cone-beam computed tomography (Other)
%K lung cancer (Other)
%K non-small cell lung cancer (Other)
%K normal tissue (Other)
%K organs at risk (Other)
%K pneumonitis (Other)
%K quality assessment (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:33363005
%2 pmc:PMC7756078
%R 10.3389/fonc.2020.564857
%U https://inrepo02.dkfz.de/record/166609