TY  - JOUR
AU  - Hoegen, Philipp
AU  - Lang, Clemens
AU  - Akbaba, Sati
AU  - Häring, Peter
AU  - Splinter, Mona
AU  - Miltner, Annette
AU  - Bachmann, Marion
AU  - Stahl-Arnsberger, Christiane
AU  - Brechter, Thomas
AU  - El Shafie, Rami A
AU  - Weykamp, Fabian
AU  - König, Laila
AU  - Debus, Jürgen
AU  - Hörner-Rieber, Juliane
TI  - Cone-Beam-CT Guided Adaptive Radiotherapy for Locally Advanced Non-small Cell Lung Cancer Enables Quality Assurance and Superior Sparing of Healthy Lung.
JO  - Frontiers in oncology
VL  - 10
SN  - 2234-943X
CY  - Lausanne
PB  - Frontiers Media
M1  - DKFZ-2020-03045
SP  - 564857
PY  - 2020
N1  - #EA:E050#LA:E050#
AB  - To evaluate the potential of cone-beam-CT (CB-CT) guided adaptive radiotherapy (ART) for locally advanced non-small cell lung cancer (NSCLC) for sparing of surrounding organs-at-risk (OAR).In 10 patients with locally advanced NSCLC, daily CB-CT imaging was acquired during radio- (n = 4) or radiochemotherapy (n = 6) for simulation of ART. Patients were treated with conventionally fractionated intensity-modulated radiotherapy (IMRT) with total doses of 60-66 Gy (pPlan) (311 fraction CB-CTs). OAR were segmented on every daily CB-CT and the tumor volumes were modified weekly depending on tumor changes. Doses actually delivered were recalculated on daily images (dPlan), and voxel-wise dose accumulation was performed using a deformable registration algorithm. For simulation of ART, treatment plans were adapted using the new contours and re-optimized weekly (aPlan).CB-CT showed continuous tumor regression of 1.1 ± 0.4
KW  - adaptive radiotherapy (Other)
KW  - cone-beam computed tomography (Other)
KW  - lung cancer (Other)
KW  - non-small cell lung cancer (Other)
KW  - normal tissue (Other)
KW  - organs at risk (Other)
KW  - pneumonitis (Other)
KW  - quality assessment (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:33363005
C2  - pmc:PMC7756078
DO  - DOI:10.3389/fonc.2020.564857
UR  - https://inrepo02.dkfz.de/record/166609
ER  -