TY  - JOUR
AU  - Schündeln, Michael M
AU  - Lange, Toni
AU  - Knoll, Maximilian
AU  - Spix, Claudia
AU  - Brenner, Hermann
AU  - Bozorgmehr, Kayvan
AU  - Stock, Christian
TI  - Statistical methods for spatial cluster detection in childhood cancer incidence: A simulation study.
JO  - Cancer epidemiology
VL  - 70
SN  - 1877-7821
CY  - Amsterdam [u.a.]
PB  - Elsevier
M1  - DKFZ-2020-03049
SP  - 101873
PY  - 2021
N1  - #LA:C070#Volume 70, February 2021, 101873
AB  - The potential existence of spatial clusters in childhood cancer incidence is a debated topic. Identification of such clusters may help to better understand etiology and develop preventive strategies. We evaluated widely used statistical approaches to cluster detection in this context.Incidence of newly diagnosed childhood cancer (140/1,000,000 children under 15 years) and nephroblastoma (7/1,000,000) was simulated. Clusters of defined size (1-50) were randomly assembled on the district level in Germany. Each cluster was simulated with different relative risk levels (1-100). For each combination 2000 iterations were done. Simulated data was then analyzed by three local clustering tests: Besag-Newell method, spatial scan statistic and Bayesian Besag-York-Mollié with Integrated Nested Laplace Approximation approach. The operating characteristics (sensitivity, specificity, predictive values, power and correct classification) of all three methods were systematically described.Performance varied considerably within and between methods, depending on the simulated setting. Sensitivity of all methods was positively associated with increasing size, incidence and RR of the high-risk area. Besag-York-Mollié showed highest specificity for minimally increased RR in most scenarios. The performance of all methods was lower in the nephroblastoma scenario compared with the scenario including all cancer cases.This study illustrates the challenge to make reliable inferences on the existence of spatial clusters based on single statistical approaches in childhood cancer. Application of multiple methods, ideally with known operating characteristics, and a critical discussion of the joint evidence seems recommendable when aiming to identify high-risk clusters.
KW  - Bayesian (Other)
KW  - Besag York Mollié (Other)
KW  - Besag-Newell (Other)
KW  - Childhood cancer (Other)
KW  - Spatial cluster (Other)
KW  - Spatial scan statistic (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:33360605
DO  - DOI:10.1016/j.canep.2020.101873
UR  - https://inrepo02.dkfz.de/record/166613
ER  -