TY  - JOUR
AU  - Akbaba, Sati
AU  - Rühle, Alexander
AU  - Rothhaar, Sofie
AU  - Zamboglou, Constantinos
AU  - Gkika, Eleni
AU  - Foerster, Robert
AU  - Oebel, Laura
AU  - Klodt, Tristan
AU  - Schmidberger, Heinz
AU  - Grosu, Anca-Ligia
AU  - Debus, Jürgen
AU  - Bostel, Tilman
AU  - Nicolay, Nils H
TI  - Treatment outcomes of elderly salivary gland cancer patients undergoing radiotherapy - results from a large multicenter analysis.
JO  - Radiotherapy and oncology
VL  - 156
SN  - 0167-8140
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DKFZ-2020-03050
SP  - 266-274
PY  - 2021
N1  - Volume 156, March 2021, Pages 266-274 / #LA:E055#
AB  - To evaluate oncological outcomes and treatment-related toxicities of elderly salivary gland cancer patients undergoing (chemo)radiotherapy.Local/locoregional control (LRC), progression-free survival (PFS) and overall survival (OS) of elderly patients ≥65 years with primary salivary gland cancers undergoing (chemo)radiotherapy between 2005 and 2020 at three tertiary cancer centers were calculated. The impact of clinicopathological and treatment parameters on outcomes were analyzed, and acute and chronic toxicities were quantified.288 elderly salivary gland cancer patients were included in this multicenter analysis, and their median LRC, PFS and OS amounted to 113, 39 and 75 months, respectively. Age, performance status, comorbidities, definitive vs. adjuvant (chemo)radiotherapy as well as locally/locoregionally advanced cancers and distant metastases correlated with reduced outcomes in elderly salivary gland patients. Patients receiving dose-escalated radiotherapy (total doses >70 GyEQD2) with carbon ion boost radiation resulted in improved LRC, but no improvements in PFS or OS. Concomitant chemoradiotherapy did not improve treatment outcomes in elderly salivary gland carcinoma patients. Radiotherapy of elderly salivary gland cancer patients resulted in moderate higher-grade toxicities despite dose escalation with 70 (24.3
KW  - Chemotherapy (Other)
KW  - Elderly patients (Other)
KW  - Geriatric patients (Other)
KW  - Head-and-neck cancer (Other)
KW  - Radiotherapy (Other)
KW  - Salivary gland cancer (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:33359662
DO  - DOI:10.1016/j.radonc.2020.12.024
UR  - https://inrepo02.dkfz.de/record/166614
ER  -