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@ARTICLE{Akbaba:166614,
      author       = {S. Akbaba$^*$ and A. Rühle$^*$ and S. Rothhaar and C.
                      Zamboglou$^*$ and E. Gkika$^*$ and R. Foerster and L.
                      Oebel$^*$ and T. Klodt$^*$ and H. Schmidberger$^*$ and A.-L.
                      Grosu$^*$ and J. Debus and T. Bostel$^*$ and N. H.
                      Nicolay$^*$},
      title        = {{T}reatment outcomes of elderly salivary gland cancer
                      patients undergoing radiotherapy - results from a large
                      multicenter analysis.},
      journal      = {Radiotherapy and oncology},
      volume       = {156},
      issn         = {0167-8140},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2020-03050},
      pages        = {266-274},
      year         = {2021},
      note         = {Volume 156, March 2021, Pages 266-274 / #LA:E055#},
      abstract     = {To evaluate oncological outcomes and treatment-related
                      toxicities of elderly salivary gland cancer patients
                      undergoing (chemo)radiotherapy.Local/locoregional control
                      (LRC), progression-free survival (PFS) and overall survival
                      (OS) of elderly patients ≥65 years with primary salivary
                      gland cancers undergoing (chemo)radiotherapy between 2005
                      and 2020 at three tertiary cancer centers were calculated.
                      The impact of clinicopathological and treatment parameters
                      on outcomes were analyzed, and acute and chronic toxicities
                      were quantified.288 elderly salivary gland cancer patients
                      were included in this multicenter analysis, and their median
                      LRC, PFS and OS amounted to 113, 39 and 75 months,
                      respectively. Age, performance status, comorbidities,
                      definitive vs. adjuvant (chemo)radiotherapy as well as
                      locally/locoregionally advanced cancers and distant
                      metastases correlated with reduced outcomes in elderly
                      salivary gland patients. Patients receiving dose-escalated
                      radiotherapy (total doses >70 GyEQD2) with carbon ion boost
                      radiation resulted in improved LRC, but no improvements in
                      PFS or OS. Concomitant chemoradiotherapy did not improve
                      treatment outcomes in elderly salivary gland carcinoma
                      patients. Radiotherapy of elderly salivary gland cancer
                      patients resulted in moderate higher-grade toxicities
                      despite dose escalation with 70 $(24.3\%)$ and 48 patients
                      $(16.7\%)$ experiencing acute and chronic grade 3
                      toxicities, respectively. No grade 4/5 toxicities were
                      observed in this patient cohort.Data from the largest
                      multicenter analysis of elderly salivary gland cancer
                      patients undergoing (chemo)radiotherapy demonstrate
                      favorable LRC and tolerable toxicity rates. Decision-making
                      for these vulnerable patients should be based on patient
                      performance rather than chronological patient age.},
      keywords     = {Chemotherapy (Other) / Elderly patients (Other) / Geriatric
                      patients (Other) / Head-and-neck cancer (Other) /
                      Radiotherapy (Other) / Salivary gland cancer (Other)},
      cin          = {FM01 / FR01 / HD01 / E050 / E055},
      ddc          = {610},
      cid          = {I:(DE-He78)FM01-20160331 / I:(DE-He78)FR01-20160331 /
                      I:(DE-He78)HD01-20160331 / I:(DE-He78)E050-20160331 /
                      I:(DE-He78)E055-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33359662},
      doi          = {10.1016/j.radonc.2020.12.024},
      url          = {https://inrepo02.dkfz.de/record/166614},
}