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@ARTICLE{Seiffert:166657,
      author       = {K. Seiffert and K. Thoene and C. Z. Eulenburg and S.
                      Behrens$^*$ and B. Schmalfeldt and H. Becher and J.
                      Chang-Claude$^*$ and I. Witzel},
      title        = {{T}he effect of family history on screening procedures and
                      prognosis in breast cancer patients - {R}esults of a large
                      population-based case-control study.},
      journal      = {The breast},
      volume       = {55},
      issn         = {0960-9776},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2021-00024},
      pages        = {98 - 104},
      year         = {2020},
      abstract     = {The potential benefit of additional breast cancer screening
                      examinations in moderate risk patients (patients with a
                      history of breast cancer in one or two family members)
                      remains unclear.A large population-based case-control study
                      on breast cancer in postmenopausal women in Germany
                      recruited 2002-2005 (3813 cases and 7341 age-matched
                      controls) was used to assess the association of family
                      history with breast cancer risk. Analysis of family history,
                      participation in screening procedures, and tumor size
                      regarding prognosis in patients was based on follow-up data
                      until 2015.A first degree family history of breast cancer
                      was associated with higher breast cancer risk (OR 1.39,
                      p < 0.001). Patients with a first degree family history of
                      breast cancer were more likely to have had >10 mammograms
                      (MG) $(42.7\%$ vs. $24.9\%,$ p < 0.001) and showed a
                      higher rate of imaging-detected tumors (MG or ultrasound)
                      $(45.8\%$ vs. $31.9\%,$ p < 0.001). A smaller tumor size
                      at initial diagnosis (below 2 cm) was more likely in
                      patients with a positive family history (OR 1.45,
                      p < 0.001) and a higher number of MG (≥10 MG: OR 2.29).
                      After accounting for tumor characteristics, mammogram
                      regularity (HR 0.72, p < 0.001) and imaging-assisted tumor
                      detection (HR 0.66, p < 0.001) were associated with better
                      overall survival but not with a positive family
                      history.Patients with a positive family history had a higher
                      rate of imaging detected tumors with smaller size at initial
                      diagnosis compared to patients without affected family
                      members. Screening was associated with improved survival
                      after a breast cancer diagnosis, irrespective of a positive
                      family history.},
      keywords     = {Breast cancer (Other) / Familial risk (Other) / Mammography
                      (Other) / Prognosis (Other) / Screening (Other)},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33395600},
      doi          = {10.1016/j.breast.2020.12.008},
      url          = {https://inrepo02.dkfz.de/record/166657},
}