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@ARTICLE{Conti:166679,
author = {D. V. Conti and B. F. Darst and L. C. Moss and E. J.
Saunders and X. Sheng and A. Chou and F. R. Schumacher and
A. A. A. Olama and S. Benlloch and T. Dadaev and M. N. Brook
and A. Sahimi and T. J. Hoffmann and A. Takahashi and K.
Matsuda and Y. Momozawa and M. Fujita and K. Muir and A.
Lophatananon and P. Wan and L. Le Marchand and L. R. Wilkens
and V. L. Stevens and S. M. Gapstur and B. D. Carter and J.
Schleutker and T. L. J. Tammela and C. Sipeky and A. Auvinen
and G. G. Giles and M. C. Southey and R. J. MacInnis and C.
Cybulski and D. Wokołorczyk and J. Lubiński and D. E. Neal
and J. L. Donovan and F. C. Hamdy and R. M. Martin and B. G.
Nordestgaard and S. F. Nielsen and M. Weischer and S. E.
Bojesen and M. A. Røder and P. Iversen and J. Batra and S.
Chambers and L. Moya and L. Horvath and J. A. Clements and
W. Tilley and G. P. Risbridger and H. Gronberg and M. Aly
and R. Szulkin and M. Eklund and T. Nordström and N.
Pashayan and A. M. Dunning and M. Ghoussaini and R. C.
Travis and T. J. Key and E. Riboli and J. Y. Park and T. A.
Sellers and H.-Y. Lin and D. Albanes and S. J. Weinstein and
L. A. Mucci and E. Giovannucci and S. Lindstrom and P. Kraft
and D. J. Hunter and K. L. Penney and C. Turman and C. M.
Tangen and P. J. Goodman and I. M. Thompson and R. J.
Hamilton and N. E. Fleshner and A. Finelli and M.-É. Parent
and J. L. Stanford and E. A. Ostrander and M. S. Geybels and
S. Koutros and L. E. B. Freeman and M. Stampfer and A. Wolk
and N. Håkansson and G. L. Andriole and R. N. Hoover and M.
J. Machiela and K. D. Sørensen and M. Borre and W. J. Blot
and W. Zheng and E. D. Yeboah and J. E. Mensah and Y.-J. Lu
and H.-W. Zhang and N. Feng and X. Mao and Y. Wu and S.-C.
Zhao and Z. Sun and S. N. Thibodeau and S. K. McDonnell and
D. J. Schaid and C. M. L. West and N. Burnet and G. Barnett
and C. Maier and T. Schnoeller and M. Luedeke and A. S.
Kibel and B. F. Drake and O. Cussenot and G. Cancel-Tassin
and F. Menegaux and T. Truong and Y. A. Koudou and E. M.
John and E. M. Grindedal and L. Maehle and K.-T. Khaw and S.
A. Ingles and M. C. Stern and A. Vega and A. Gómez-Caamaño
and L. Fachal and B. S. Rosenstein and S. L. Kerns and H.
Ostrer and M. R. Teixeira and P. Paulo and A. Brandão and
S. Watya and A. Lubwama and J. T. Bensen and E. T. H.
Fontham and J. Mohler and J. A. Taylor and M. Kogevinas and
J. Llorca and G. Castaño-Vinyals and L. Cannon-Albright and
C. C. Teerlink and C. D. Huff and S. S. Strom and L.
Multigner and P. Blanchet and L. Brureau and R. Kaneva and
C. Slavov and V. Mitev and R. J. Leach and B. Weaver and H.
Brenner$^*$ and K. Cuk$^*$ and B. Holleczek and K.-U.
Saum$^*$ and E. A. Klein and A. W. Hsing and R. A. Kittles
and A. B. Murphy and C. J. Logothetis and J. Kim and S. L.
Neuhausen and L. Steele and Y. C. Ding and W. B. Isaacs and
B. Nemesure and A. J. M. Hennis and J. Carpten and H. Pandha
and A. Michael and K. De Ruyck and G. De Meerleer and P. Ost
and J. Xu and A. Razack and J. Lim and S.-H. Teo and L. F.
Newcomb and D. W. Lin and J. H. Fowke and C. Neslund-Dudas
and B. A. Rybicki and M. Gamulin and D. Lessel and T. Kulis
and N. Usmani and S. Singhal and M. Parliament and F.
Claessens and S. Joniau and T. Van den Broeck and M.
Gago-Dominguez and J. E. Castelao and M. E. Martinez and S.
Larkin and P. A. Townsend and C. Aukim-Hastie and W. S. Bush
and M. C. Aldrich and D. C. Crawford and S. Srivastava and
J. C. Cullen and G. Petrovics and G. Casey and M. J. Roobol
and G. Jenster and R. H. N. van Schaik and J. J. Hu and M.
Sanderson and R. Varma and R. McKean-Cowdin and M. Torres
and N. Mancuso and S. I. Berndt and S. K. Van Den Eeden and
D. F. Easton and S. J. Chanock and M. B. Cook and F. Wiklund
and H. Nakagawa and J. S. Witte and R. A. Eeles and Z.
Kote-Jarai and C. A. Haiman},
title = {{T}rans-ancestry genome-wide association meta-analysis of
prostate cancer identifies new susceptibility loci and
informs genetic risk prediction.},
journal = {Nature genetics},
volume = {53},
number = {1},
issn = {1546-1718},
address = {London},
publisher = {Macmillan Publishers Limited, part of Springer Nature},
reportid = {DKFZ-2021-00032},
pages = {65 - 75},
year = {2021},
abstract = {Prostate cancer is a highly heritable disease with large
disparities in incidence rates across ancestry populations.
We conducted a multiancestry meta-analysis of prostate
cancer genome-wide association studies (107,247 cases and
127,006 controls) and identified 86 new genetic risk
variants independently associated with prostate cancer risk,
bringing the total to 269 known risk variants. The top
genetic risk score (GRS) decile was associated with odds
ratios that ranged from 5.06 $(95\%$ confidence interval
(CI), 4.84-5.29) for men of European ancestry to 3.74
$(95\%$ CI, 3.36-4.17) for men of African ancestry. Men of
African ancestry were estimated to have a mean GRS that was
2.18-times higher $(95\%$ CI, 2.14-2.22), and men of East
Asian ancestry 0.73-times lower $(95\%$ CI, 0.71-0.76), than
men of European ancestry. These findings support the role of
germline variation contributing to population differences in
prostate cancer risk, with the GRS offering an approach for
personalized risk prediction.},
cin = {C070 / HD01 / C120},
ddc = {570},
cid = {I:(DE-He78)C070-20160331 / I:(DE-He78)HD01-20160331 /
I:(DE-He78)C120-20160331},
pnm = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
pid = {G:(DE-HGF)POF4-313},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:33398198},
doi = {10.1038/s41588-020-00748-0},
url = {https://inrepo02.dkfz.de/record/166679},
}