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000166690 1001_ $$aZhu, Jun-Yi$$b0
000166690 245__ $$aAutophagy inhibition rescues structural and functional defects caused by the loss of mitochondrial chaperone Hsc70-5 in Drosophila.
000166690 260__ $$aAbingdon, Oxon$$bTaylor & Francis$$c2021
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000166690 520__ $$aWe investigated in larval and adult Drosophila models whether loss of the mitochondrial chaperone Hsc70-5 is sufficient to cause pathological alterations commonly observed in Parkinson disease. At affected larval neuromuscular junctions, no effects on terminal size, bouton size or number, synapse size, or number were observed, suggesting that we studied an early stage of pathogenesis. At this stage, we noted a loss of synaptic vesicle proteins and active zone components, delayed synapse maturation, reduced evoked and spontaneous excitatory junctional potentials, increased synaptic fatigue, and cytoskeleton rearrangements. The adult model displayed ATP depletion, altered body posture, and susceptibility to heat-induced paralysis. Adult phenotypes could be suppressed by knockdown of dj-1β, Lrrk, DCTN2-p50, DCTN1-p150, Atg1, Atg101, Atg5, Atg7, and Atg12. The knockdown of components of the macroautophagy/autophagy machinery or overexpression of human HSPA9 broadly rescued larval and adult phenotypes, while disease-associated HSPA9 variants did not. Overexpression of Pink1 or promotion of autophagy exacerbated defects.
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000166690 650_7 $$2Other$$a Atg1 
000166690 650_7 $$2Other$$a Hsc70-5 
000166690 650_7 $$2Other$$amicrotubule
000166690 650_7 $$2Other$$amitochondria
000166690 650_7 $$2Other$$amitophagy
000166690 650_7 $$2Other$$arapamycin
000166690 650_7 $$2Other$$asynapse
000166690 7001_ $$0P:(DE-He78)77839d5cf53d09e62bdfca3d3172fab1$$aHannan, Shabab Bin$$b1
000166690 7001_ $$0P:(DE-He78)44dc011368b331679dbc8d341ae41420$$aDräger, Nina$$b2
000166690 7001_ $$aVereshchagina, Natalia$$b3
000166690 7001_ $$aKrahl, Ann-Christin$$b4
000166690 7001_ $$aFu, Yulong$$b5
000166690 7001_ $$aElliott, Christopher J H$$b6
000166690 7001_ $$aHan, Zhe$$b7
000166690 7001_ $$0P:(DE-He78)813a306749dc9a24333a77867a42bbd9$$aJahn, Thomas$$b8
000166690 7001_ $$0P:(DE-He78)e9a603e8a132f8501ed78cf4995c246c$$aRasse, Tobias$$b9$$eLast author
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000166690 9141_ $$y2021
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