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@ARTICLE{Zwicker:166693,
      author       = {F. Zwicker$^*$ and H. Hauswald and K.-J. Weber and J.
                      Debus$^*$ and P. Huber$^*$},
      title        = {{I}n {V}ivo {E}valuation of {C}ombined {CK}2 {I}nhibition
                      and {I}rradiation in {H}uman {W}i{D}r {T}umours.},
      journal      = {In vivo},
      volume       = {35},
      number       = {1},
      issn         = {1791-7549},
      address      = {Kapandriti, Attiki},
      publisher    = {IIAR},
      reportid     = {DKFZ-2021-00046},
      pages        = {111 - 117},
      year         = {2021},
      note         = {#EA:E050#LA:E055#},
      abstract     = {Casein kinase 2 (CK2) which sustains multiple pro-survival
                      functions in cellular DNA-damage response, is strictly
                      regulated in normal cells but elevated in cancer. CK2 is
                      considered as a potential therapeutic target, and its
                      inhibition has been associated with radiosensitization in
                      mammalian cells in vitro. Here, we investigated potential
                      radiosensitization by CK2 inhibition in vivo.The effect of
                      CK2 inhibition in vivo was investigated in human
                      WiDr-xenograft tumours grown subcutaneously on BALB/c nu/nu
                      mice with and without fractionated irradiation. CK2
                      inhibition was performed using the specific inhibitor
                      tetra-bromobenzotriazole (TBB). Histological examinations
                      included staining for apoptosis and double-strand
                      breaks.Both TBB treatment alone and radiation alone
                      significantly reduced tumour growth, which was reflected by
                      increased apoptosis rates. However, TBB treatment did not
                      boost radiation-induced tumour growth suppression in
                      combined treatment, although the apoptosis rate increased
                      and repair of double-strand breaks was reduced. This was in
                      stark contrast to previous data on in vitro
                      radiosensitization.The absence of radiosensitization by CK2
                      inhibition should be investigated in different tumour
                      models.},
      keywords     = {CK2 inhibition (Other) / TBB (Other) / human WiDr tumours
                      (Other) / irradiation (Other) / tetra-bromobenzotriazole
                      (Other)},
      cin          = {E050 / E055},
      ddc          = {610},
      cid          = {I:(DE-He78)E050-20160331 / I:(DE-He78)E055-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33402456},
      doi          = {10.21873/invivo.12238},
      url          = {https://inrepo02.dkfz.de/record/166693},
}