TY  - JOUR
AU  - Culliford, Richard
AU  - Cornish, Alex J
AU  - Law, Philip J
AU  - Farrington, Susan M
AU  - Palin, Kimmo
AU  - Jenkins, Mark A
AU  - Casey, Graham
AU  - Hoffmeister, Michael
AU  - Brenner, Hermann
AU  - Chang-Claude, Jenny
AU  - Kirac, Iva
AU  - Maughan, Tim
AU  - Brezina, Stefanie
AU  - Gsur, Andrea
AU  - Cheadle, Jeremy P
AU  - Aaltonen, Lauri A
AU  - Dunlop, Malcom G
AU  - Houlston, Richard S
TI  - Lack of an association between gallstone disease and bilirubin levels with risk of colorectal cancer: a Mendelian randomisation analysis.
JO  - British journal of cancer
VL  - 124
IS  - 6
SN  - 1532-1827
CY  - Edinburgh
PB  - Nature Publ. Group
M1  - DKFZ-2021-00063
SP  - 1169-1174
PY  - 2021
N1  - 2021 Mar;124(6):1169-1174
AB  - Epidemiological studies of the relationship between gallstone disease and circulating levels of bilirubin with risk of developing colorectal cancer (CRC) have been inconsistent. To address possible confounding and reverse causation, we examine the relationship between these potential risk factors and CRC using Mendelian randomisation (MR).We used two-sample MR to examine the relationship between genetic liability to gallstone disease and circulating levels of bilirubin with CRC in 26,397 patients and 41,481 controls. We calculated the odds ratio per genetically predicted SD unit increase in log bilirubin levels (ORSD) for CRC and tested for a non-zero causal effect of gallstones on CRC. Sensitivity analysis was applied to identify violations of estimator assumptions.No association between either gallstone disease (P value = 0.60) or circulating levels of bilirubin (ORSD = 1.00, 95
LB  - PUB:(DE-HGF)16
C6  - pmid:33414539
DO  - DOI:10.1038/s41416-020-01211-x
UR  - https://inrepo02.dkfz.de/record/166716
ER  -