%0 Journal Article
%A Schmidt, Simon
%A Flassbeck, Sebastian
%A Schmelter, Sonja
%A Schmeyer, Ellen
%A Ladd, Mark E
%A Schmitter, Sebastian
%T The impact of 4D flow displacement artifacts on wall shear stress estimation.
%J Magnetic resonance in medicine
%V 85
%N 6
%@ 0740-3194
%C New York, NY [u.a.]
%I Wiley-Liss
%M DKFZ-2021-00069
%P 3154-3168
%D 2021
%Z #EA:E020#LA:E020# / 2021 Jun;85(6):3154-3168
%X To investigate the amplitude and spatial distribution of errors in wall shear stress (WSS) values derived from 4D flow measurements caused by displacement artifacts intrinsic to the 4D flow acquisition.Phase-contrast MRI velocimetry was performed in a model of a stenotic aorta using two different timing schemes, both of which are commonly applied in vivo but differ in their resulting displacement artifacts. Whereas one scheme is optimized to minimize the duration of the encoding gradients (herein called FAST), the other aims to specifically minimize displacement artifacts by synchronizing all three spatial-encoding time points (called ECHO). WSS estimates were calculated and compared to unbiased WSS values obtained by a 5-hour single-point imaging acquisition. In addition, MRI simulations based on computational fluid dynamics data were carried out to investigate the impact of gradient timings corresponding to different spatial resolutions.4D flow displacement artifacts were found to have an impact on the quantified WSS peak values, spatial location, and overall WSS pattern. FAST leads to the underestimation of local WSS values in the phantom arch by up to 90
%K 4D flow MRI (Other)
%K displacement artifact (Other)
%K phase-contrast MRI (Other)
%K wall shear stress (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:33421221
%R 10.1002/mrm.28641.
%U https://inrepo02.dkfz.de/record/166722