TY  - JOUR
AU  - Schmidt, Simon
AU  - Flassbeck, Sebastian
AU  - Schmelter, Sonja
AU  - Schmeyer, Ellen
AU  - Ladd, Mark E
AU  - Schmitter, Sebastian
TI  - The impact of 4D flow displacement artifacts on wall shear stress estimation.
JO  - Magnetic resonance in medicine
VL  - 85
IS  - 6
SN  - 0740-3194
CY  - New York, NY [u.a.]
PB  - Wiley-Liss
M1  - DKFZ-2021-00069
SP  - 3154-3168
PY  - 2021
N1  - #EA:E020#LA:E020# / 2021 Jun;85(6):3154-3168
AB  - To investigate the amplitude and spatial distribution of errors in wall shear stress (WSS) values derived from 4D flow measurements caused by displacement artifacts intrinsic to the 4D flow acquisition.Phase-contrast MRI velocimetry was performed in a model of a stenotic aorta using two different timing schemes, both of which are commonly applied in vivo but differ in their resulting displacement artifacts. Whereas one scheme is optimized to minimize the duration of the encoding gradients (herein called FAST), the other aims to specifically minimize displacement artifacts by synchronizing all three spatial-encoding time points (called ECHO). WSS estimates were calculated and compared to unbiased WSS values obtained by a 5-hour single-point imaging acquisition. In addition, MRI simulations based on computational fluid dynamics data were carried out to investigate the impact of gradient timings corresponding to different spatial resolutions.4D flow displacement artifacts were found to have an impact on the quantified WSS peak values, spatial location, and overall WSS pattern. FAST leads to the underestimation of local WSS values in the phantom arch by up to 90
KW  - 4D flow MRI (Other)
KW  - displacement artifact (Other)
KW  - phase-contrast MRI (Other)
KW  - wall shear stress (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:33421221
DO  - DOI:10.1002/mrm.28641.
UR  - https://inrepo02.dkfz.de/record/166722
ER  -