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@ARTICLE{Kratz:167192,
      author       = {C. P. Kratz and M. C. Jongmans and H. Cavé and K. Wimmer
                      and S. Behjati and L. Guerrini-Rousseau and T. Milde$^*$ and
                      K. W. Pajtler$^*$ and L. Golmard and M. Gauthier-Villars and
                      R. Jewell and C. Duncan and E. R. Maher and L. Brugieres and
                      K. Pritchard-Jones and F. Bourdeaut},
      title        = {{P}redisposition to cancer in children and adolescents.},
      journal      = {The lancet child $\&$ adolescent health},
      volume       = {5},
      number       = {2},
      issn         = {2352-4642},
      address      = {Kidlington, Oxford},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2021-00183},
      pages        = {142 - 154},
      year         = {2021},
      abstract     = {Childhood malignancies are rarely related to known
                      environmental exposures, and it has become increasingly
                      evident that inherited genetic factors play a substantial
                      causal role. Large-scale sequencing studies have shown that
                      approximately $10\%$ of children with cancer have an
                      underlying cancer predisposition syndrome. The number of
                      recognised cancer predisposition syndromes and cancer
                      predisposition genes are constantly growing. Imaging and
                      laboratory technologies are improving, and knowledge of the
                      range of tumours and risk of malignancy associated with
                      cancer predisposition syndromes is increasing over time.
                      Consequently, surveillance measures need to be constantly
                      adjusted to address these new findings. Management
                      recommendations for individuals with pathogenic germline
                      variants in cancer predisposition genes need to be
                      established through international collaborative studies,
                      addressing issues such as genetic counselling, cancer
                      prevention, cancer surveillance, cancer therapy,
                      psychological support, and social-ethical issues. This
                      Review represents the work by a group of experts from the
                      European Society for Paediatric Oncology (SIOPE) and aims to
                      summarise the current knowledge and define future research
                      needs in this evolving field.},
      subtyp        = {Review Article},
      cin          = {B310 / HD01 / B062},
      ddc          = {610},
      cid          = {I:(DE-He78)B310-20160331 / I:(DE-He78)HD01-20160331 /
                      I:(DE-He78)B062-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33484663},
      doi          = {10.1016/S2352-4642(20)30275-3},
      url          = {https://inrepo02.dkfz.de/record/167192},
}